Inhibitors

Inhibitor refers to substance that can hinder the chemical reactions, biological reactions (including immune response) and biological activity. In present time, commonly used inhibitors include immunosuppressants and inhibitors.

1. Immunosuppressive agents: immunosuppressants system refers to drug that can reduce the immune response. It can selectively suppress certain steps of the immune response and immune cells. Immune response refers to the body’s response to a variety of pathogenic substances. Some reactions are favorable to the body and can enhance the body's resistance to disease; some have adverse effects on the body and can cause tissue damage or disorders of physiological functions (allergy). Therefore, patients suffering from allergic reactions being harmful to the body should be subject to the treatment of immunosuppressant to affect the related immune processes and reduce the immune response of the body.

For the treatment of various autoimmune diseases and weakening the tissue incompatibility, it has been developed of a variety of immunosuppressive agents, some of which have been widely used in clinical practice. Commonly used immunosuppressants include glucocorticoids (prednisone, prednisolone, etc.), alkylating agents (nitric oxide mustard, cyclophosphamide, thiotepa, busulfan, etc.), and antimetabolites (6- mercaptopurine, azathioprine, methotrexate, etc.).

The mechanism of immunosuppressants, though not entirely clear, but is characterized by the following several aspects:
① most kinds of immunosuppressants can simultaneously inhibit cellular and humoral immunity and can be used for organ transplantation and autoimmune disease.
②Its inhibitory effect is strong for the primary immune response while the inhibitory effect against secondary response is weak.
③It can simultaneously act on normal and pathological immunity, therefore, can often lead to some complications.
④These drugs often have strong with serious adverse reactions.

2. Enzyme inhibitors: Enzyme inhibitors refer to compounds or drugs being capable of binding to enzyme and inhibit the enzymatic activity. It is clinically often applied of enzyme inhibitors to specially interfere with certain metabolic system to achieve the therapeutic purposes. For example, people use monoamine oxidase inhibitors as antidepressants; use carbonic anhydrase inhibitors as diuretics; use dopa decarboxylase inhibitors as antihypertensive drugs and use antibiotics such as penicillin, cephalosporins belonging to cell wall synthesis inhibitors. Enzyme inhibitors have applications in veterinary medicine and agriculture. In addition, people can also apply enzyme inhibitors to study the mechanism of the enzyme and metabolic pathways.

Enzyme inhibitors often have similar structure with their natural substrates. For designing the inhibitors according modification of natural substrate, people should first analyze and decide the function of each part of the molecule in binding with enzymes: for binding or not binding or repulsion; secondly, people should know the degree of tolerance of the binding site to the adjacent steric hindrance. Then people can replace each functional group to regulate the strength of interaction with the enzyme.

Inhibitors can be divided into reversible and irreversible, two classes. (1)Inhibitors binding with enzyme through non-covalent bonds are called reversible inhibitor. (2)Inhibitors binding to the enzyme via a covalent bond are irreversible inhibitors with strong binding affinity. They will not be affected by concentration change process such as dialysis or dilution after binding to the enzyme.

Click on the specific product, view the latest prices of the products, information, serving information
Structure Chemical Name CAS MF
EST EST 88321-09-9 C17H30N2O5
PI-103 PI-103 371935-74-9 C19H16N4O3
Andarine Andarine 401900-40-1 C19H18F3N3O6
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile 500287-72-9 C22H18N6
Danusertib Danusertib 827318-97-8 C26H30N6O3
5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL 5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL 213261-59-7 C14H12O3S2
SIRTINOL SIRTINOL 410536-97-9 C26H22N2O2
Pizotifen Malate Pizotifen Malate 5189-11-7 C23H27NO5S
Nitenpyram Nitenpyram 150824-47-8 C11H15ClN4O2
Ifosfamide Ifosfamide 3778-73-2 C7H15Cl2N2O2P
Naloxone hydrochloride dihydrate Naloxone hydrochloride dihydrate 51481-60-8 C19H26ClNO6
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 1268524-70-4 C23H25ClN4O2S
Vilazodone Hydrochloride Vilazodone Hydrochloride 163521-08-2 C26H28ClN5O2
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione 648450-29-7 C12H7N3O2S
MK-2206 2HCl MK-2206 2HCl 1032350-13-2 C25H22ClN5O
3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide 860352-01-8 C17H19FN4O2S
PF-562271 PF-562271 717907-75-0 C21H20F3N7O3S
Tariquidar Tariquidar 206873-63-4 C38H38N4O6
Torcetrapib Torcetrapib 262352-17-0 C26H25F9N2O4
Rupatadine Fumarate Rupatadine Fumarate 182349-12-8 C26H26ClN3.C4H4O4
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid 10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid 74711-43-6 C17H14O3S
KU-0063794 KU-0063794 938440-64-3 C25H31N5O4
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide 702675-74-9 C23H26IN7O2S
N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide 726169-73-9 C23H20N6O
GW788388 GW788388 452342-67-5 C25H23N5O2
LY2109761 LY2109761 700874-71-1 C26H27N5O2
Naratriptan Hydrochloride Naratriptan Hydrochloride 143388-64-1 C17H25N3O2S.ClH
T0070907 T0070907 313516-66-4 C12H8ClN3O3
Cilomilast Cilomilast 153259-65-5 C20H25NO4
SNS-032 SNS-032 345627-80-7 C17H24N4O2S2
Cyclosporin A Cyclosporin A 59865-13-3 C62H111N11O12
WZ4002 WZ4002 1213269-23-8 C25H27ClN6O3
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea 950769-58-1 C29H32N6O4S
Daclatasvir Daclatasvir 1009119-64-5 C40H50N8O6
NVP-BGJ398 NVP-BGJ398 872511-34-7 C26H31Cl2N7O3
Ledipasvir Ledipasvir 1256388-51-8 C49H54F2N8O6
JTT-705 JTT-705 211513-37-0 C23H35NO2S
Cyclophosphamide monohydrate Cyclophosphamide monohydrate 6055-19-2 C7H17Cl2N2O3P
ENALAPRILAT DIHYDRATE ENALAPRILAT DIHYDRATE 84680-54-6 C18H26N2O6
Eflone Eflone 3801-06-7 C24H31FO5
Fenazox Fenazox 61618-27-7 C15H16NNaO4
Panobinostat Panobinostat 404950-80-7 C21H23N3O2
AZD 5438 AZD 5438 602306-29-6 C18H21N5O2S
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE 49843-98-3 C13H13ClN2O
Linsitinib Linsitinib 867160-71-2 C26H23N5O
MLN-8237 MLN-8237 1028486-01-2 C27H20ClFN4O4
Alectinib Alectinib 1256580-46-7 C30H34N4O2
GSK1349572 GSK1349572 1051375-16-6 C20H19F2N3O5
Suvorexant Suvorexant 1030377-33-3 C23H23ClN6O2
ZM 336372 ZM 336372 208260-29-1 C23H23N3O3
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide 108605-62-5 C12H9F3N2O2
MOEXIPRIL HYDROCHLORIDE MOEXIPRIL HYDROCHLORIDE 82586-52-5 C27H35ClN2O7
Necrostatin-1 Necrostatin-1 4311-88-0 C13H13N3OS
Semagacestat Semagacestat 425386-60-3 C19H27N3O4
Ataluren (PTC124) Ataluren (PTC124) 775304-57-9 C15H9FN2O3
NVP-TAE684 NVP-TAE684 761439-42-3 C30H40ClN7O3S
Elvitegravir Elvitegravir 697761-98-1 C23H23ClFNO5
N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide 850879-09-3 C23H21N5O3S
Foretinib (GSK1363089) Foretinib (GSK1363089) 849217-64-7 C34H34F2N4O6
R-406 R-406 841290-80-0 C22H23FN6O5
XL147 XL147 956958-53-5 C21H16N6O2S2
Ostarine Ostarine 841205-47-8 C19H14F3N3O3
LY 2157299 LY 2157299 700874-72-2 C22H19N5O
(R)-Baclofen (R)-Baclofen 69308-37-8 C10H12ClNO2
ZSTK474 ZSTK474 475110-96-4 C19H21F2N7O2
PLERIXAFOR PLERIXAFOR 110078-46-1 C28H54N8
8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione 155270-99-8 C20H24N4O4
Dovitinib Dovitinib 405169-16-6 C21H21FN6O
N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide 936091-26-8 C27H36N6O3S
2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone 371242-69-2 C22H19N7O
Omarigliptin (MK-3102) Omarigliptin (MK-3102) 1226781-44-7 C17H20F2N4O3S
PD184352 PD184352 212631-79-3 C17H14ClF2IN2O2
LUMIRACOXIB LUMIRACOXIB 220991-20-8 C15H13ClFNO2
Obatoclax mesilate Obatoclax mesilate 803712-79-0 C20H19N3O.CH4O3S
GF109203X GF109203X 133052-90-1 C25H24N4O2
Prucalopride Prucalopride 179474-81-8 C18H26ClN3O3
HA14-1 HA14-1 65673-63-4 C17H17BrN2O5
ABT 263 ABT 263 923564-51-6 C47H55ClF3N5O6S3
Mirabegron Mirabegron 223673-61-8 C21H24N4O2S
Momelotinib Momelotinib 1056634-68-4 C23H22N6O2
Bardoxolone methyl Bardoxolone methyl 218600-53-4 C32H43NO4
BIBW2992 DiMaleate BIBW2992 DiMaleate 850140-73-7 C28H29ClFN5O7
CO-1686 CO-1686 1374640-70-6 C27H28F3N7O3
ALMOTRIPTAN ALMOTRIPTAN 181183-52-8 C21H31N3O7S
VARESPLADIB VARESPLADIB 172732-68-2 C21H20N2O5
Orantinib (SU6668) Orantinib (SU6668) 252916-29-3 C18H18N2O3
BI 2536 BI 2536 755038-02-9 C28H39N7O3
BUCLIZINE, DIHYDROCHLORIDE BUCLIZINE, DIHYDROCHLORIDE 129-74-8 C28H35Cl3N2
lubiprostone lubiprostone 333963-40-9 C20H32F2O5
Lumacaftor (VX-809) Lumacaftor (VX-809) 936727-05-8 C24H18F2N2O5
SRT1720 SRT1720 1001645-58-4 C25H24ClN7OS
Azilsartan Medoxomil Azilsartan Medoxomil 863031-21-4 C30H24N4O8
(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one 1032754-93-0 C23H30N8O3S
Dabrafenib Dabrafenib 1195765-45-7 C23H20F3N5O2S2
Belinostat (PXD101) Belinostat (PXD101) 414864-00-9 C15H14N2O4S
API-2 API-2 35943-35-2 C13H16N6O4
(R)-Tomoxetine (R)-Tomoxetine 83015-26-3 C17H21NO
GW9662 GW9662 22978-25-2 C13H9ClN2O3
SU 11274 SU 11274 658084-23-2 C28H30ClN5O4S
TRAM-34 TRAM-34 289905-88-0 C22H17ClN2
Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.