Proteases

Proteases are the major pathway in the degradation of misfolded protein in protein synthesis and other proteolyzed protein, which are found in all eukaryotic cells, archaea, and some bacteria. Proteases, composed of plural Catalytic protein and regulatory protein, have multiple catalytic activities. It has three to four kinds of different peptidase activities, including the hydrolysis activity of tryptase, chymotrypsin-like enzyme and peptidylglutamyl-peptide. Depending on the sedimentation coefficient, it can be divided into two types of proteases: the 26S proteasome, of which the molecular weight is about 2000 kDa, dependent on ATP; and 20S proteasome, of which relative molecular mass of about 750 kDa, independent on ATP. The degradation of most protein by the proteasome requires ubiquitination.

26s proteasome is a multi-subunit protease of 2-MDa, which can degrade most of the cytoplasm, endoplasmic reticulum and nucleoprotein. The most understood target protein degradation mechanism is ubiquitin degradation via ubiquitin, an 8-kDa protein. 26s proteasome is composed of a core protein of 20s and the regulatory complex composition of 19s .The chaperone of 19s can unfold ubiquitin-labeled protein substrate and send it into the graphics core of 20s, where there are three pairs of proteolytic active sites, whose names are corresponding to the specific similarity to the cleavage specificity of chymotrypsin, trypsin and caspase. Studies on bud yeast mutants ultimately suggest the different role of these three pairs of sites. And the chymotrypsin-like active sites are most crucial to normal and regular growth. Proteasome inhibitors have been applied in the treatment of diseases such as cancer as well as widely used in laboratory studies. MG-341 is an FDA-approved medication for multiple myeloma and mantle cell lymphoma. It can also be used in laboratory studies to inhibit the activity of proteasome. Other protease inhibitors including disulfiram, epigallocatechin-3-gallate, salinosporamide A, carfilzomib, ONX0912, CEP-18770 and MLN9708 have also been developed or are in clinical trials for drugs and testing phase.

MG132, also known as Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, is a peptide aldehyde, capable of inhibiting the activity of different types of proteases, including serine proteases and calpains. MG132 and other peptide aldehydes can effectively inhibit the protease activity of several peptidases in Proteasome as well as the activity of calpains.

Click on the specific product, view the latest prices of the products, information, serving information
Structure Chemical Name CAS MF
Carfilzomib Carfilzomib 868540-17-4 C40H57N5O7
MG-132 MG-132 133407-82-6 C26H41N3O5
DAPT DAPT 208255-80-5 C23H26F2N2O4
Telaprevir Telaprevir 402957-28-2 C36H53N7O6
Doxycycline hydrochloride Doxycycline hydrochloride 10592-13-9 C22H25ClN2O8
Nelfinavir mesylate Nelfinavir mesylate 159989-65-8 C33H49N3O7S2
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) 850649-61-5 C18H21N5O2
Nafamostat mesylate Nafamostat mesylate 82956-11-4 C21H25N5O8S2
Daclatasvir Daclatasvir 1009119-64-5 C40H50N8O6
Ledipasvir Ledipasvir 1256388-51-8 C49H54F2N8O6
Semagacestat Semagacestat 425386-60-3 C19H27N3O4
EST EST 88321-09-9 C17H30N2O5
Omarigliptin (MK-3102) Omarigliptin (MK-3102) 1226781-44-7 C17H20F2N4O3S
Avagacestat (BMS-708163) Avagacestat (BMS-708163) 1146699-66-2 C20H17ClF4N4O4S
Unii-33o78xf0bw Unii-33o78xf0bw 635728-49-3 C29H43N3O8S
DIBENZAZEPINE DIBENZAZEPINE 209984-56-5 C26H23F2N3O3
RG7227, ITMN-191, RO5190591 RG7227, ITMN-191, RO5190591 850876-88-9 C35H46FN5O9S
cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid 471905-41-6 C21H21ClF2O4S
CJC1295 CJC1295 863288-34-0 C152H252N44O42
AZD 9668 AZD 9668 848141-11-7 C25H22F3N5O4S
Ilomastat Ilomastat 142880-36-2 C20H28N4O4
RO4929097 RO4929097 847925-91-1 C22H20F5N3O3
Teneligliptin  Hydrobromide Teneligliptin Hydrobromide 906093-29-6 C22H31BrN6OS
Batimastat Batimastat 130370-60-4 C23H31N3O4S2
LY411575 LY411575 209984-57-6 C26H23F2N3O4
ONX-0914 ONX-0914 960374-59-8 C31H40N4O7
Cathepsin Inhibitor 1 Cathepsin Inhibitor 1 225120-65-0 C20H24ClN5O2
PD 151746 PD 151746 179461-52-0 C11H8FNO2S
Marimastat Marimastat 154039-60-8 C15H29N3O5
PI-1840 PI-1840 1401223-22-0 C22H26N4O3
CEP-18770 CEP-18770 847499-27-8 C21H28BN3O5
E-64C E-64C 76684-89-4 C15H26N2O5
CALPEPTIN CALPEPTIN 117591-20-5 C20H30N2O4
MK-0822 MK-0822 603139-19-1 C25H27F4N3O3S
VX-222 VX-222 1026785-59-0 C25H35NO4S
Oprozomib Oprozomib 935888-69-0 C25H32N4O7S
Trelagliptin Trelagliptin 865759-25-7 C18H20FN5O2
Calpain Inhibitor I Calpain Inhibitor I 110044-82-1 C20H37N3O4
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid 1072833-77-2 C14H19BCl2N2O4
MLN9708 MLN9708 1201902-80-8 C20H23BCl2N2O9
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide 7497-07-6 C12H15Cl2NO
FLI-06 FLI-06 313967-18-9 C25H30N2O5
MMP-2/MMP-9 INHIBITOR IV MMP-2/MMP-9 INHIBITOR IV 292605-14-2 C15H14O3S2
Z-PHE-DL-ALA-FLUOROMETHYLKETONE Z-PHE-DL-ALA-FLUOROMETHYLKETONE 197855-65-5 C21H23FN2O4
  • 1
Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.