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| | Marimastat Basic information |
| Product Name: | Marimastat | | Synonyms: | Marimastat;(2R,3S)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4,3-dihydroxy-2-isobutylsuccinamide;(2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide;(2R,3S)-N1-((S)-3,3-diMethyl-1-(MethylaMino)-1-oxobutan-2-yl)-N4;BB 2516;GI 5712;KB-R 8898;TA 2516 | | CAS: | 154039-60-8 | | MF: | C15H29N3O5 | | MW: | 331.41 | | EINECS: | | | Product Categories: | API | | Mol File: | 154039-60-8.mol |  |
| | Marimastat Chemical Properties |
| Melting point | 148℃ | | density | 1.140±0.06 g/cm3(Predicted) | | RTECS | EJ6665000 | | storage temp. | -20°C | | solubility | DMSO: ≥20mg/mL | | form | White solid | | pka | 9.44±0.40(Predicted) |
| WGK Germany | 3 | | HS Code | 29241990 |
| | Marimastat Usage And Synthesis |
| Uses | Antineoplastic (matrix metalloproteinase inhibitor). | | Uses | Marimastat acts as a matrix metalloproteinase inhibitor in the treatment of various cancers, and pathological occurrences such as arthritis and atherosclerosis. | | Uses | Marimastat has been used as an inhibitor of:
- metalloproteinase 2/9 (MMP2/9), to study its effects on exercise-mediated interleukin-6 (IL-6) release in mice
- metalloproteinase, to determine protease activity in Pseudomonas aeruginosa cultures
- metalloproteinase 10 (MMP10), to study its effect on monoclonal antibody H3 binding to MMP10
| | Definition | ChEBI: Marimastat is a secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide. It has a role as an antineoplastic agent and a matrix metalloproteinase inhibitor. It is a secondary carboxamide and a hydroxamic acid. | | General Description | An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo. | | Biological Activity | Broad spectrum inhibitor of matrix metalloprotease (MMP) (IC 50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). In vivo inhibits peritoneal dissemination of human gastric cancer cells through inhibition of tumor angiogenesis. | | Biochem/physiol Actions | Marimastat is a broad spectrum matrix metalloprotease (MMP) inhibitor | | storage | Store at -20°C |
| | Marimastat Preparation Products And Raw materials |
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