FLI-06

FLI-06 Basic information
Product Name:FLI-06
Synonyms:FLI-06;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06;3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor;FLI-06 |FLI06;Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;CS-1434
CAS:313967-18-9
MF:C25H30N2O5
MW:438.52
EINECS:
Product Categories:Inhibitors
Mol File:313967-18-9.mol
FLI-06 Structure
FLI-06 Chemical Properties
Melting point 199-202oC
Boiling point 597.5±50.0 °C(Predicted)
density 1.25±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka0.78±0.70(Predicted)
form powder
color white to beige
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Safety Information
RIDADR 3077
WGK Germany 3
HS Code 29339900
MSDS Information
FLI-06 Usage And Synthesis
DescriptionFLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1
UsesFLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.
References1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731
FLI-06 Preparation Products And Raw materials
DIBENZAZEPINE CHIR-99021 RO4929097 KPT-330 LY411575 Semagacestat SGC-GAK-1 xav-939 2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Fatostatin A

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