Metabolism

Speaking from a wide range of metabolism means the sum of the body to maintain all the chemical reactions necessary for life, and from a small scope for all aspects of metabolism: energy metabolism, gas metabolism, amino acid metabolism, and glucose metabolism, etc. Metabolism is the metabolic transformation of exogenous chemicals in vivo by enzymatic reaction and non-enzymatic reaction in the field of toxicology, also known as biotransformation. Biotransformation reactions can be divided into the phaseⅠ and phaseⅡ. Most of exogenous chemicals have to undergo the two phase reaction, but a few only by one of the two phases. The result of the phaseⅠreaction is that the water solubility is improved and it is easy to be discharged with urine. The phase Ⅱ reaction is further improve the water solubility, and has the potential to increase the molecular weight (such as the formation of the grape glycosides acid and/or combination with glutathione). When the molecular weight of the conjugate is greater than 325, it is easy to discharge into the intestinal tract with the bile. In addition to making it easy to exogenous chemicals to be excreted, changes in the chemical structure often result in loss of inactivation or decreased activity. Therefore, metabolic transformation is often seen as a detoxication. But sometimes it is the opposite result improved toxicity, which is known as a toxication or activation or bioactiva-tion. The vast majority of poison metabolism in the body not only to participate in a single reaction, but a plurality of reactions have been carried out. The activation of chemicals may be the result of a reaction, or a series of reactions, and also may be activated before detoxification. The reaction product of metabolic transformation is called metabolite. A chemical can have a variety of metabolites, some of which are reactive metabolite, they have different levels of activity. Most of the two-phase reaction involve enzymatic reactions. These enzymes are often generally referred to as metabolic enzymes, metabolic enzyme or drug metabolizing enzymes. Induction of enzyme, enzyme induction.

Energy metabolism refers to the process of energy production and consumption in the process of body material metabolism (metabolism). Material metabolism is the most basic feature of all life activities. Metabolism process can be divided into two aspects: one is the anabolism and also called assimilation, including the generation of repair and energy storage of body tissue; on the other hand is the catabolism and also called alienation effect, including tissue decomposition and energy consumption. The sum of the anabolism and catabolism is called material metabolism.

In general, when catabolism, macromolecules are broken down into small molecules, chemical energy stored in macromolecules is released in the process; whereas anabolism, small molecules into large molecules, this process requires energy, it must be obtained from catabolism. The energy released by catabolism, in addition to the anabolism, the rest is converted into heat energy and mechanical energy, and radiant energy and power. So metabolism must be accompanied by transfer of energy, this energy conversion process of biological is called energy metabolism.

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Structure Chemical Name CAS MF
Abiraterone Abiraterone 154229-19-3 C24H31NO
Apremilast Apremilast 608141-41-9 C22H24N2O7S
Tetrahydropapaverine hydrochloride Tetrahydropapaverine hydrochloride 6429-04-5 C20H25NO4.HCl
Vardenafil Vardenafil 224785-90-4 C23H32N6O4S
ROLIPRAM ROLIPRAM 61413-54-5 C16H21NO3
Brinzolamide Brinzolamide 138890-62-7 C12H21N3O5S3
URB597 URB597 546141-08-6 C20H22N2O3
Ozagrel hydrochloride Ozagrel hydrochloride 78712-43-3 C13H13ClN2O2
Apixaban Apixaban 503612-47-3 C25H25N5O4
Rosiglitazone hydrochloride Rosiglitazone hydrochloride 302543-62-0 C18H20ClN3O3S
Anacetrapib Anacetrapib 875446-37-0 C30H25F10NO3
Pimobendan Pimobendan 74150-27-9 C19H18N4O2
Bexarotene Bexarotene 153559-49-0 C24H28O2
Safinamide Safinamide 133865-89-1 C17H19FN2O2
Dorzolamide Hydrochloride Dorzolamide Hydrochloride 130693-82-2 C10H17ClN2O4S3
Tamibarotene Tamibarotene 94497-51-5 C22H25NO3
Rasagiline mesylate Rasagiline mesylate 161735-79-1 C13H17NO3S
Anagrelide hydrochloride Anagrelide hydrochloride 58579-51-4 C10H8Cl3N3O
PF 3845 PF 3845 1196109-52-0 C24H23F3N4O2
4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide 188591-46-0 C15H12ClF3N2O3S
3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide 348622-88-8 C15H24N4O4
DARAPLADIB DARAPLADIB 356057-34-6 C36H38F4N4O2S
MK8245 MK8245 1030612-90-8 C17H16BrFN6O4
Nepicastat  hydrochloride Nepicastat hydrochloride 170151-24-3 C14H16ClF2N3S
NLG919 NLG919 1402836-58-1 C18H22N2O
VARESPLADIB VARESPLADIB 172732-68-2 C21H20N2O5
LONAFARNIB LONAFARNIB 193275-84-2 C27H31Br2ClN4O2
GW9662 GW9662 22978-25-2 C13H9ClN2O3
Torcetrapib Torcetrapib 262352-17-0 C26H25F9N2O4
Avasimibe Avasimibe 166518-60-1 C29H43NO4S
DGAT-1 inhibitor DGAT-1 inhibitor 959122-11-3 C26H24N2O4
6-[[3-[(Dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-3-quinolinecarboxamide 6-[[3-[(Dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-3-quinolinecarboxamide 801312-28-7 C27H26N4O5S
AGI6780 AGI6780 1432660-47-3 C21H18F3N3O3S2
APREMILAST (PDE inhibitor) APREMILAST (PDE inhibitor)
Cilomilast Cilomilast 153259-65-5 C20H25NO4
Octanoic acid, 6,8-bis[(phenylMethyl)thio]- Octanoic acid, 6,8-bis[(phenylMethyl)thio]- 95809-78-2 C22H28O2S2
N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide 1355326-35-0 C27H31FN4O2
JTT-705 JTT-705 211513-37-0 C23H35NO2S
S- (+)-Rolipram S- (+)-Rolipram 85416-73-5 C16H21NO3
Tipifarnib Tipifarnib 192185-72-1 C27H22Cl2N4O
U-73122 U-73122 112648-68-7 C29H40N2O3
(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE (E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE 658084-64-1 C24H29N3O2
SteMRegenin 1 SteMRegenin 1 1227633-49-9 C24H23N5OS
Cobicistat Cobicistat 1004316-88-4 C40H53N7O5S2
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide 108605-62-5 C12H9F3N2O2
Fenspiride hydrochloride Fenspiride hydrochloride 5053-08-7 C15H21ClN2O2
LY-2484595 LY-2484595 1186486-62-3 C31H36F6N6O2
PluriSln 1 PluriSln 1 91396-88-2 C12H11N3O
Avanafil Avanafil 330784-47-9 C23H26ClN7O3
Pioglitazone Pioglitazone 111025-46-8 C19H20N2O3S
Tolcapone Tolcapone 134308-13-7 C14H11NO5
WY-14643 WY-14643 50892-23-4 C14H14ClN3O2S
Sildenafil citrate Sildenafil citrate 171599-83-0 C28H38N6O11S
ISOVALERAMIDE ISOVALERAMIDE 541-46-8 C5H11NO
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 571203-78-6 C30H31ClN4O4
TAK-700 TAK-700 426219-18-3 C18H17N3O2
CYP3cide CYP3cide 1390637-82-7 C26H32N8
Liproxstatin-1 Liproxstatin-1 950455-15-9 C19H21ClN4
TTNPB (Arotinoid Acid) TTNPB (Arotinoid Acid) 71441-28-6 C24H28O2
Mildronate dihydrate Mildronate dihydrate 86426-17-7 C6H14N2O2.2H2O
1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide 301326-22-7 C19H19N5O
CP 91149 CP 91149 186392-40-5 C21H21ClN3O3
Deltarasin Deltarasin 1440898-61-2 C40H37N5O
indoleaMine-2,3-dioxygenase inhibitor INCB024360 indoleaMine-2,3-dioxygenase inhibitor INCB024360 914471-09-3 C9H7ClFN5O2
FTI 277 HYDROCHLORIDE FTI 277 HYDROCHLORIDE 180977-34-8 C22H30ClN3O3S2
Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2
PF-2545920 PF-2545920 1292799-56-4 C25H20N4O
LB 42708 LB 42708 226929-39-1 C30H27BrN4O2
GW0742 GW0742 317318-84-6 C21H17F4NO3S2
PF-04620110 PF-04620110 1109276-89-2 C21H24N4O4
UM729 UM729 1448723-60-1 C20H25N5O2
Edoxaban (tosylate Monohydrate) Edoxaban (tosylate Monohydrate) 1229194-11-9 C31H38ClN7O7S2
2H-IMidazole-2-thione, 5-(aMinoMethyl)-1-[(2R)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-, 2H-IMidazole-2-thione, 5-(aMinoMethyl)-1-[(2R)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-, 195881-94-8 C14H16ClF2N3S
JNJ 1661010 JNJ 1661010 681136-29-8 C19H19N5OS
Safinamide mesylate Safinamide mesylate 202825-46-5 C17H19FN2O2.CH4O3S
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Carbonic Anhydrase IX/XII Inhibitor II(U-104) 178606-66-1 C13H12FN3O3S
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