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| | DGAT-1 inhibitor Basic information |
| Product Name: | DGAT-1 inhibitor | | Synonyms: | (1R,2R)-2-[[4'-[[(Phenylamino)carbonyl]amino][1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid;DGAT-1 inhibitor;Diacyl glycerolacyltransferase 1 inhibitor;A922500;A922500(DGAT-1 Inhibitor 4a);enylureido)biphenyl(1R,2R)-2-(4'-(3-phcarbonyl)cyclopentanecarboxylic acid;DGAT-1 Inhibitor 4a;(1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)cyclopentanecarboxylic acid | | CAS: | 959122-11-3 | | MF: | C26H24N2O4 | | MW: | 428.48 | | EINECS: | | | Product Categories: | Inhibitor;Inhibitors;APIs | | Mol File: | 959122-11-3.mol |  |
| | DGAT-1 inhibitor Chemical Properties |
| density | 1.323 | | storage temp. | -20°C | | solubility | ≥21.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH | | form | Light yellow solid |
| Hazard Codes | T,N | | Risk Statements | 25-36-50 | | Safety Statements | 26-45-61 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | DGAT-1 inhibitor Usage And Synthesis |
| Uses | A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages. | | Definition | ChEBI: A 922500 is an aromatic ketone. | | Biological Activity | Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active. | | Biochem/physiol Actions | The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease. |
| | DGAT-1 inhibitor Preparation Products And Raw materials |
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