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| | Ozagrel hydrochloride Basic information |
| Product Name: | Ozagrel hydrochloride | | Synonyms: | OKY-046, (E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrate hydrochloride;Ozagrel hydrate hydrochloride;Domenan;OKY-046 HCl;Vega;Ozagrel hydrochloride hydrate,(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate, OKY-046;(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid,hydrochloride (1:1);(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate | | CAS: | 78712-43-3 | | MF: | C13H13ClN2O2 | | MW: | 264.71 | | EINECS: | 928-470-0 | | Product Categories: | Inhibitors;Piperidones ,Piperidines ,Homopiperidines;Cardiovascular | | Mol File: | 78712-43-3.mol |  |
| | Ozagrel hydrochloride Chemical Properties |
| Melting point | 214-217° | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | H2O: soluble | | form | solid | | color | white to off-white | | Merck | 14,6980 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. | | CAS DataBase Reference | 78712-43-3(CAS DataBase Reference) |
| RIDADR | 3077 | | WGK Germany | 2 | | RTECS | UD3380000 | | HS Code | 29332900 |
| | Ozagrel hydrochloride Usage And Synthesis |
| Description | Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM).1?Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2?isomerase (IC50 > 1 mM).1?Inhibits platelet aggregation2?in vitro?and arachidonate-induced arterial contraction?in vivo. Ozagrel HCl protects against arachidonate-induced sudden death in the rabbit3, and alleviates liver injury induced by acetaminophen overdose in mice4. | | Uses | Ozagrel Hydrochloride is a selective thromboxane A2 synthase inhibitor, which alleviates liver injury induced by acetaminophen overdose in mice. | | Uses | Antithrombotic;Thromboxane synthase inhibitor | | Definition | ChEBI: Ozagrel hydrochloride is an organic molecular entity. | | References | 1) Hiraku?et al. (1986),?Pharmacological studies on the TXA2?synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046); Jpn. J. Pharmacol.,?41?393
2) Naito?et al. (1983), Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets; Eur. J. Pharmacol.,?91?41
3) Edmonds and Leffer (1984),?Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death; Life Sci.,?35?1763
4) Tomishima?et al. (2013),?Ozagrel hydrochloride, a selective thromboxane A2?synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice; BMC Gastroenterol.,?30?13 |
| | Ozagrel hydrochloride Preparation Products And Raw materials |
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