ChemicalBook Product Catalog Biochemical Engineering Inhibitors Apoptosis Bcl-2 inhibitors HA14-1

HA14-1

HA14-1 Basic information
Product Name:HA14-1
Synonyms:2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(4H)-1-benzopyrane-4-aceticacidethylester;ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate;2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester, Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate;[Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate], Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate;2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester;2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester;Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate 97%;HA 14-1, Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate, 2-[2-Amino-6-bromo-3-(ethoxycarbonyl)-4H-chromen-4-yl]-3-ethoxy-3-oxopropanenitrile
CAS:65673-63-4
MF:C17H17BrN2O5
MW:409.23
EINECS:
Product Categories:Inhibitors;Caspases/Apoptosis;Inhibitor
Mol File:65673-63-4.mol
HA14-1 Structure
HA14-1 Chemical Properties
Melting point 105 °C
density 1.480
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO: 26 mg/mL
form powder
CAS DataBase Reference65673-63-4
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29322090
MSDS Information
ProviderLanguage
SigmaAldrich English
HA14-1 Usage And Synthesis
UsesHA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.
DefinitionChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.
Biological ActivityCell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.
Biochem/physiol ActionsHA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.
HA14-1 Preparation Products And Raw materials
Raw materials5-Bromosalicylaldehyde-->Ethyl cyanoacetate
3-(3-BROMO-PHENYL)-PROPAN-1-OL Ethyl 2-cyanopropanoate 3-(2-HYDROXY-PHENYL)-PROPIONIC ACID ETHYL ESTER 1-ALLYL-3-BROMOBENZENE 3-(3-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER 2-CYANO-3-PHENYLPROPIONIC ACID ETHYL 2-CYANO-4-METHYLVALERATE 3-(3-BROMO-PHENYL)-PROPIONALDEHYDE 3-(3-Bromophenyl)-2-methylprop-1-ene ETHYL 2-CYANOVALERATE 3-(5-BROMO-2-METHOXY-PHENYL)-PROPIONALDEHYDE 3-(5-BROMO-2-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER ETHYL 2-CYANOBUTANOATE 2-Cyano-pentanedioic acid diethyl ester ethyl 2-cyano-3-phenyl-propanoate 3-(3-BROMOPHENYL)PROPIONITRILE 3-(5-bromo-2-methoxy-phenyl)propionitrile DIETHYL 2-METHYLGLUTARATE
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