Quinoline compounds

Quinoline and isoquinoline are two isomers of benzo pyridine, both present in coal tar. The quinoline and isoquinoline and their many substituted derivatives, all can get from cyclizing benzene derivatives by the ring system. The basic reaction of synthesizing quinoline ring compound is that get aniline, glycerol, sulfuric acid and oxidizing agent (nitrobenzene, etc.) heated together. Since glycerol is dehydrated to become acrolein and then react with aniline, various aniline derivatives and other α, β- unsaturated carbonyl compounds can be used to synthesize quinoline compounds which has a substituent on a ring. Such as 4-methyl-quinoline (Le Puy-pyridine) is obtained from aniline and methyl - vinyl ketone . The way to synthesize Other quinoline compounds synthesis including the condensation of anthranilic ketone formaldehyde condensation. Such as 2-methyl-quinoline (QUINALDINIC) is prepared by the condensation of o-benzaldehyde and acetone.

Quinoline compound refers quinoline and its homologue, a bicyclic aromatics with nitrogen(hetero). Quinoline compounds are known as the heavy pyridine which is called tar base together with pyridine bases, a basic product obtained from high-temperature coal tar processing, including quinoline,isoquinoline, quinoline methyl and dimethyl quinoline and so on. Quinoline compounds mainly exist in the coal tar naphthalene oil fraction and wash oil fraction.The content of quinoline compounds in coal tar is about 0.3% to 0.5%. Quinoline compounds have a special smell, when they are exposed to air or sunlight the color becomes deeper gradually.

Quinoline compounds can be used to produce medicine, dyes, photographic materials, rubber, solvents and chemical reagents. Quinoline medicine is primarily used in the manufacture of niacin-based, 8-hydroxy quinoline and quinine-based drugs. Niacin-based drugs including nicotinamide, tonic, stimulant and treatment of tapeworm medicine; 8-hydroxy quinoline can be used to make the treatment of amoebic coccidiosis medicine, trauma disinfectants, mildew and textile auxiliaries and the like. Primaquine Ning, quinine chloride and hydroxylamine quinine is a synthetic treatment of malaria medicine. Isoquinoline can be used in the manufacture of pesticides, antimalarials, rubber vulcanization accelerator and determination of rare metals by chemical agents. Methyl-quinoline can be used for the manufacture of color film sensitizing agent and dye, also used as a solvent, impregnating agents, corrosion inhibitors, quinine-based drugs and pesticides. The extraction of quinoline compounds is same as the heavy pyridine refined.

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Structure Chemical Name CAS MF
Chiniofon Chiniofon 547-91-1 C9H6INO4S
Quinaldic acid Quinaldic acid 93-10-7 C10H7NO2
4-Bromoisoquinoline 4-Bromoisoquinoline 1532-97-4 C9H6BrN
2,8-Bis(trifluoromethyl)-4-quinolinol 2,8-Bis(trifluoromethyl)-4-quinolinol 35853-41-9 C11H5F6NO
6-BROMO-2-CHLORO-QUINOLINE 6-BROMO-2-CHLORO-QUINOLINE 1810-71-5 C9H5BrClN
6-Aminoquinoline 6-Aminoquinoline 580-15-4 C9H8N2
4-methylquinoline 4-methylquinoline 491-35-0 C10H9N
7-Chloroquinolin-4-ol 7-Chloroquinolin-4-ol 86-99-7 C9H6ClNO
7-Hydroxyquinoline 7-Hydroxyquinoline 580-20-1 C9H7NO
6-Hydroxyquinoline 6-Hydroxyquinoline 580-16-5 C9H7NO
4-Bromomethyl-1,2-dihydroquinoline-2-one 4-Bromomethyl-1,2-dihydroquinoline-2-one 4876-10-2 C10H8BrNO
6-Methoxyquinoline 6-Methoxyquinoline 5263-87-6 C10H9NO
2,8-Quinolinediol 2,8-Quinolinediol 15450-76-7 C9H7NO2
2-Chloro-4-amino-6,7-dimethoxyquinazoline 2-Chloro-4-amino-6,7-dimethoxyquinazoline 23680-84-4 C10H10ClN3O2
5,7-Dichloro-8-hydroxyquinoline 5,7-Dichloro-8-hydroxyquinoline 773-76-2 C9H5Cl2NO
4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 1701-24-2 C10H5ClF3N
7-Chloro-2-methylquinoline 7-Chloro-2-methylquinoline 4965-33-7 C10H8ClN
5-Isoquinolinesulfonic acid 5-Isoquinolinesulfonic acid 27655-40-9 C9H7NO3S
QUINOLINE-8-SULFONIC ACID QUINOLINE-8-SULFONIC ACID 85-48-3 C9H7NO3S
4-HYDROXY-1-METHYL-2-QUINOLONE 4-HYDROXY-1-METHYL-2-QUINOLONE 1677-46-9 C10H9NO2
5,6,7,8-Tetrahydroquinolin-8-ol 5,6,7,8-Tetrahydroquinolin-8-ol 14631-46-0 C9H11NO
1,2,3,4-Tetrahydro-8-hydroxyquinoline 1,2,3,4-Tetrahydro-8-hydroxyquinoline 6640-50-2 C9H11NO
2-Phenylquinoline 2-Phenylquinoline 612-96-4 C15H11N
4-Aminomethylquinoline hydrochloride 4-Aminomethylquinoline hydrochloride 5632-13-3 C10H10N2
3-Chloroisoquinoline 3-Chloroisoquinoline 19493-45-9 C9H6ClN
Isoquinolin-6-ol Isoquinolin-6-ol 7651-82-3 C9H7NO
8-FLUOROQUINOLINE 8-FLUOROQUINOLINE 394-68-3 C9H6FN
4-Bromoquinoline 4-Bromoquinoline 3964-04-3 C9H6BrN
3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone 129722-34-5 C13H16BrNO2
Benzoyleneurea Benzoyleneurea 86-96-4 C8H6N2O2
8-Nitroquinoline 8-Nitroquinoline 607-35-2 C9H6N2O2
4-chloro-6,7-dimethoxyquinoline 4-chloro-6,7-dimethoxyquinoline 35654-56-9 C11H10ClNO2
1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 14099-81-1 C9H12ClN
8-Chloroisoquinoline 8-Chloroisoquinoline 34784-07-1 C9H6ClN
8-Hydroxyquinoline-N-oxide 8-Hydroxyquinoline-N-oxide 1127-45-3 C9H7NO2
2-Chloro-6-methyl-3-quinolinecarbaldehyde 2-Chloro-6-methyl-3-quinolinecarbaldehyde 73568-27-1 C11H8ClNO
5-Hydroxyisoquinoline 5-Hydroxyisoquinoline 2439-04-5 C9H7NO
Methyl 3-isoquinolinecarboxylate Methyl 3-isoquinolinecarboxylate 27104-73-0 C11H9NO2
6-CHLORO-2-METHYLQUINOLINE 6-CHLORO-2-METHYLQUINOLINE 92-46-6 C10H8ClN
2-Methylquinoxaline 2-Methylquinoxaline 7251-61-8 C9H8N2
2,4-DIAMINO-5-FLUOROQUINAZOLINE 2,4-DIAMINO-5-FLUOROQUINAZOLINE 119584-70-2 C8H7FN4
2-CHLORO-6-METHOXYQUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-METHOXYQUINOLINE-3-CARBALDEHYDE 73568-29-3 C11H8ClNO2
5-CHLOROQUINOLINE 5-CHLOROQUINOLINE 635-27-8 C9H6ClN
5,7-DIBROMO-8-HYDROXYQUINOLINE 5,7-DIBROMO-8-HYDROXYQUINOLINE 521-74-4 C9H5Br2NO
5-Amino-6-nitroquinoline 5-Amino-6-nitroquinoline 35975-00-9 C9H7N3O2
2-CHLOROLEPIDINE 2-CHLOROLEPIDINE 634-47-9 C10H8ClN
3-Aminoquinoline 3-Aminoquinoline 580-17-6 C9H8N2
Nitroxoline Nitroxoline 4008-48-4 C9H6N2O3
2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid 5162-90-3 C12H12N2O3
6-METHOXY-8-NITROQUINOLINE 6-METHOXY-8-NITROQUINOLINE 85-81-4 C10H8N2O3
2,4-Dichloroquinazoline 2,4-Dichloroquinazoline 607-68-1 C8H4Cl2N2
3-Isoquinolinecarbonitrile 3-Isoquinolinecarbonitrile 26947-41-1 C10H6N2
6-BROMO-2(1H)-QUINOLONE 6-BROMO-2(1H)-QUINOLONE 1810-66-8 C9H6BrNO
Isoquinoline-1-carboxylic acid Isoquinoline-1-carboxylic acid 486-73-7 C10H7NO2
Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate Ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 79660-46-1 C12H8F3NO3
2-CHLORO-8-METHYL-3-QUINOLINE CARBOXALDEHYDE 2-CHLORO-8-METHYL-3-QUINOLINE CARBOXALDEHYDE 73568-26-0 C11H8ClNO
2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE 2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE 25199-84-2 C10H6F3NO
6-Iodoquinoline 6-Iodoquinoline 13327-31-6 C9H6IN
ETHYL 6-FLUORO-4-HYDROXY-3-QUINOLINECARBOXYLATE ETHYL 6-FLUORO-4-HYDROXY-3-QUINOLINECARBOXYLATE 318-35-4 C12H10FNO3
8-Hydroxyquinoline-2-carboxaldehyde 8-Hydroxyquinoline-2-carboxaldehyde 14510-06-6 C10H7NO2
7-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE 7-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE 57124-20-6 C10H5ClF3NO
5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 220514-28-3 C9H8BrNO4
7-(TRIFLUOROMETHYL)-4-QUINOLINOL 7-(TRIFLUOROMETHYL)-4-QUINOLINOL 322-97-4 C10H6F3NO
QUINOLINE HYDROCHLORIDE QUINOLINE HYDROCHLORIDE 530-64-3 C9H8ClN
6-QUINOLINEACETIC ACID 6-QUINOLINEACETIC ACID 5622-34-4 C11H9NO2
5-(4-Chlorobutyl)-1-cyclohexanyl tetrazole 5-(4-Chlorobutyl)-1-cyclohexanyl tetrazole 73963-42-5 C11H19ClN4
5-FLUORO-8-HYDROXYQUINOLINE 5-FLUORO-8-HYDROXYQUINOLINE 387-97-3 C9H6FNO
4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER 4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLIC ETHYL ESTER 23851-84-5 C13H10F3NO3
4,8-DICHLOROQUINOLINE 4,8-DICHLOROQUINOLINE 21617-12-9 C9H5Cl2N
4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID 28027-17-0 C11H9NO4
7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 7-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 17680-55-6 C9H10BrN
3-Cyanoquinoline 3-Cyanoquinoline 34846-64-5 C10H6N2
6-Chloro-4-hydroxyquinazoline 6-Chloro-4-hydroxyquinazoline 16064-14-5 C8H5ClN2O
Cloquintocet-mexyl Cloquintocet-mexyl 99607-70-2 C18H22ClNO3
Quinoline-5-carboxaldehyde Quinoline-5-carboxaldehyde 22934-41-4 C10H7NO
6-Bromoquinazolin-4-ol 6-Bromoquinazolin-4-ol 32084-59-6 C8H5BrN2O
5,7-DICHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE 5,7-DICHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE 59108-13-3 C10H4Cl2F3NO
N-Benzylcinchonidinium chloride N-Benzylcinchonidinium chloride 69257-04-1 C26H29ClN2O
8-CHLOROQUINALDINE 8-CHLOROQUINALDINE 3033-82-7 C10H8ClN
4-CHLORO-2-METHYLQUINOLINE 4-CHLORO-2-METHYLQUINOLINE 4295-06-1 C10H8ClN
1-ETHYLQUINALDINIUM IODIDE 1-ETHYLQUINALDINIUM IODIDE 606-55-3 C12H14IN
QUINOLINE-2-CARBONITRILE QUINOLINE-2-CARBONITRILE 1436-43-7 C10H6N2
6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 343-10-2 C10H6FNO3
4-CHLORO-6-METHOXYQUINOLINE 4-CHLORO-6-METHOXYQUINOLINE 4295-04-9 C10H8ClNO
4-Aminoguinoline 4-Aminoguinoline 578-68-7 C9H8N2
4-Hydroxy-2-methylquinoline 4-Hydroxy-2-methylquinoline 607-67-0 C10H9NO
6-FLUORO-4-HYDROXY-2-METHYLQUINOLINE 6-FLUORO-4-HYDROXY-2-METHYLQUINOLINE 15912-68-2 C10H8FNO
3-Hydroxyquinoline 3-Hydroxyquinoline 580-18-7 C9H7NO
1-Aminoisoquinoline 1-Aminoisoquinoline 1532-84-9 C9H8N2
1-ETHYLQUINOLINIUM IODIDE 1-ETHYLQUINOLINIUM IODIDE 634-35-5 C11H12IN
Quinoline-N-oxide Quinoline-N-oxide 1613-37-2 C9H7NO
6-Methylisoquinoline 6-Methylisoquinoline 42398-73-2 C10H9N
3-NITRO-4-QUINOLINOL 3-NITRO-4-QUINOLINOL 50332-66-6 C9H6N2O3
Quinoline-7-carbaldehyde Quinoline-7-carbaldehyde 49573-30-0 C10H7NO
7-BROMO-1-CHLOROISOQUINOLINE 7-BROMO-1-CHLOROISOQUINOLINE 215453-51-3 C9H5BrClN
6-AMINO-2-METHYLQUINOLINE 6-AMINO-2-METHYLQUINOLINE 65079-19-8 C10H10N2
6-ISOPROPYLQUINOLINE 6-ISOPROPYLQUINOLINE 135-79-5 C12H13N
4-HYDROXY-8-BROMOQUINOLINE 4-HYDROXY-8-BROMOQUINOLINE 57798-00-2 C9H6BrNO
5-FLUORO-4-HYDROXYQUINAZOLINE 5-FLUORO-4-HYDROXYQUINAZOLINE 436-72-6 C8H5FN2O
8-Bromomethylquinoline 8-Bromomethylquinoline 7496-46-0 C10H8BrN
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