Quinoline compounds

Quinoline and isoquinoline are two isomers of benzo pyridine, both present in coal tar. The quinoline and isoquinoline and their many substituted derivatives, all can get from cyclizing benzene derivatives by the ring system. The basic reaction of synthesizing quinoline ring compound is that get aniline, glycerol, sulfuric acid and oxidizing agent (nitrobenzene, etc.) heated together. Since glycerol is dehydrated to become acrolein and then react with aniline, various aniline derivatives and other α, β- unsaturated carbonyl compounds can be used to synthesize quinoline compounds which has a substituent on a ring. Such as 4-methyl-quinoline (Le Puy-pyridine) is obtained from aniline and methyl - vinyl ketone . The way to synthesize Other quinoline compounds synthesis including the condensation of anthranilic ketone formaldehyde condensation. Such as 2-methyl-quinoline (QUINALDINIC) is prepared by the condensation of o-benzaldehyde and acetone.

Quinoline compound refers quinoline and its homologue, a bicyclic aromatics with nitrogen(hetero). Quinoline compounds are known as the heavy pyridine which is called tar base together with pyridine bases, a basic product obtained from high-temperature coal tar processing, including quinoline,isoquinoline, quinoline methyl and dimethyl quinoline and so on. Quinoline compounds mainly exist in the coal tar naphthalene oil fraction and wash oil fraction.The content of quinoline compounds in coal tar is about 0.3% to 0.5%. Quinoline compounds have a special smell, when they are exposed to air or sunlight the color becomes deeper gradually.

Quinoline compounds can be used to produce medicine, dyes, photographic materials, rubber, solvents and chemical reagents. Quinoline medicine is primarily used in the manufacture of niacin-based, 8-hydroxy quinoline and quinine-based drugs. Niacin-based drugs including nicotinamide, tonic, stimulant and treatment of tapeworm medicine; 8-hydroxy quinoline can be used to make the treatment of amoebic coccidiosis medicine, trauma disinfectants, mildew and textile auxiliaries and the like. Primaquine Ning, quinine chloride and hydroxylamine quinine is a synthetic treatment of malaria medicine. Isoquinoline can be used in the manufacture of pesticides, antimalarials, rubber vulcanization accelerator and determination of rare metals by chemical agents. Methyl-quinoline can be used for the manufacture of color film sensitizing agent and dye, also used as a solvent, impregnating agents, corrosion inhibitors, quinine-based drugs and pesticides. The extraction of quinoline compounds is same as the heavy pyridine refined.

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Structure Chemical Name CAS MF
2-METHYL-6-NITROQUINOLINE 2-METHYL-6-NITROQUINOLINE 613-30-9 C10H8N2O2
Kelex-100 Kelex-100 73545-11-6 C20H29NO
8-HYDROXYQUINOLINE-2-CARBOXYLIC ACID 8-HYDROXYQUINOLINE-2-CARBOXYLIC ACID 1571-30-8 C10H7NO3
7-CHLORO-4-HYDROXY QUINOLINE-3-CARBOXYLIC ACID 7-CHLORO-4-HYDROXY QUINOLINE-3-CARBOXYLIC ACID 86-47-5 C10H6ClNO3
2,4-DIHYDROXYQUINOLINE MONOSODIUM SALT 2,4-DIHYDROXYQUINOLINE MONOSODIUM SALT 4510-76-3 C9H8NNaO2
QUINOLINE ISO-AMYL IODIDE QUINOLINE ISO-AMYL IODIDE 54899-89-7 C14H18IN
8-HYDROXYQUINOLINE-7-CARBOXYLIC ACID 8-HYDROXYQUINOLINE-7-CARBOXYLIC ACID 19829-79-9 C10H7NO3
7-Aminoquinoline 7-Aminoquinoline 580-19-8 C9H8N2
Dimethyl 2,3-quinolinedicarboxylate Dimethyl 2,3-quinolinedicarboxylate 17507-03-8 C13H11NO4
HYDROQUINIDINE HYDROCHLORIDE HYDROQUINIDINE HYDROCHLORIDE 1476-98-8 C20H27ClN2O2
4,6-DICHLOROQUINOLINE 4,6-DICHLOROQUINOLINE 4203-18-3 C9H5Cl2N
6-Methoxy-3,4-dihydro-1H-quinolin-2-one 6-Methoxy-3,4-dihydro-1H-quinolin-2-one 54197-64-7 C10H11NO2
2-AMINO-4-HYDROXYQUINOLINE HYDRATE 2-AMINO-4-HYDROXYQUINOLINE HYDRATE 42712-64-1 C9H8N2O
N-BENZYLQUININIUM CHLORIDE N-BENZYLQUININIUM CHLORIDE 67174-25-8 C27H31ClN2O2
7-BROMO-4-HYDROXYQUINOLINE 7-BROMO-4-HYDROXYQUINOLINE 82121-06-0 C9H6BrNO
6,7-DIMETHOXYISOQUINOLINE 6,7-DIMETHOXYISOQUINOLINE 15248-39-2 C11H11NO2
2-AMINO-8-HYDROXYQUINOLINE 2-AMINO-8-HYDROXYQUINOLINE 70125-16-5 C9H8N2O
7-N-PROPYL-8-HYDROXYQUINOLINE 7-N-PROPYL-8-HYDROXYQUINOLINE 58327-60-9 C12H13NO
1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL 14446-24-3 C9H11NO
6-BROMO-2-QUINAZOLINAMINE 6-BROMO-2-QUINAZOLINAMINE 791626-58-9 C9H7BrN2
N-BENZYLCINCHONINIUM CHLORIDE N-BENZYLCINCHONINIUM CHLORIDE 69221-14-3 C26H29ClN2O
8-Isoquinolinol 8-Isoquinolinol 3482-14-2 C9H7NO
2-METHYL-6-ETHOXYQUINOLINE 2-METHYL-6-ETHOXYQUINOLINE 6628-28-0 C12H13NO
QUINOLINE N-OXIDE HYDRATE QUINOLINE N-OXIDE HYDRATE 64201-64-5 C9H9NO2
8-ETHOXYQUINOLINE-5-SULFONIC ACID 8-ETHOXYQUINOLINE-5-SULFONIC ACID 15301-40-3 C11H11NO4S
4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID 4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID 574-92-5 C11H6F3NO3
2,3-Pyridinedicarboxylic acid 2,3-Pyridinedicarboxylic acid 339155-13-4 C7H5NO4
7-BENZYLOXY-4-CHLOROQUINOLINE 7-BENZYLOXY-4-CHLOROQUINOLINE 178984-56-0 C16H12ClNO
4-Chloro-6-methylquinoline 4-Chloro-6-methylquinoline 18436-71-0 C10H8ClN
4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 26892-90-0 C12H11NO3
CINCHONIDINE SULFATE CINCHONIDINE SULFATE 524-61-8 C38H46N4O6S
1,2,3,4-TETRAHYDROQUINOLIN-6-OL 1,2,3,4-TETRAHYDROQUINOLIN-6-OL 3373-00-0 C9H11NO
4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 34785-11-0 C10H7NO3
2-Bromomethylquinoline 2-Bromomethylquinoline 5632-15-5 C10H8BrN
8-METHOXY-2-METHYLQUINOLINE 8-METHOXY-2-METHYLQUINOLINE 3033-80-5 C11H11NO
CARBOSTYRIL 124 CARBOSTYRIL 124 19840-99-4 C10H10N2O
n-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide n-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide 848133-76-6 C14H12ClN3O2
5,8-Dibromoisoquinoline 5,8-Dibromoisoquinoline 81045-39-8 C9H5Br2N
CINCHONINE SULFATE CINCHONINE SULFATE 5949-16-6 C38H46N4O6S
CINCHONINE HYDROCHLORIDE CINCHONINE HYDROCHLORIDE 24302-67-8 C19H23ClN2O
2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE 35853-45-3 C11H4BrF6N
2-CHLORO-3-QUINOLINECARBOXYLIC ACID 2-CHLORO-3-QUINOLINECARBOXYLIC ACID 73776-25-7 C10H6ClNO2
6-HYDROXY-3,4-DIHYDROQUINAZOLONE 6-HYDROXY-3,4-DIHYDROQUINAZOLONE 16064-10-1 C8H6N2O2
2-Methyl-6-quinolinecarbaldehyde 2-Methyl-6-quinolinecarbaldehyde 108166-03-6 C11H9NO
7-Hydroxy-1,2,3,4-tetrahydroquinoline 7-Hydroxy-1,2,3,4-tetrahydroquinoline 58196-33-1 C9H11NO
2-METHYL-8-NITROQUINOLINE 2-METHYL-8-NITROQUINOLINE 881-07-2 C10H8N2O2
6-Bromo-1,3-dichloroisoquinoline 6-Bromo-1,3-dichloroisoquinoline 552331-05-2 C9H4BrCl2N
ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE ETHYL 4-HYDROXY-6-METHOXYQUINOLINE-3-CARBOXYLATE 77156-78-6 C13H13NO4
2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DIPOTASSIUM SALT TRIHYDRATE 2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DIPOTASSIUM SALT TRIHYDRATE 63451-34-3 C20H13KN2O4
4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-HYDROXY-7-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 63463-15-0 C13H13NO4
7-CHLORO-4-HYDRAZINOQUINOLINE 7-CHLORO-4-HYDRAZINOQUINOLINE 23834-14-2 C9H8ClN3
7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE 7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE 7640-33-7 C9H5BrClNO
2-TRIFLUOROMETHYLQUINOLINE 2-TRIFLUOROMETHYLQUINOLINE 347-42-2 C10H6F3N
6-METHOXY-4-METHYLQUINOLINE 6-METHOXY-4-METHYLQUINOLINE 41037-26-7 C11H11NO
8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL 8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL 59108-43-9 C10H5BrF3NO
NNMTi NNMTi 42464-96-0
4-BROMO-8-METHOXYQUINOLINE 4-BROMO-8-METHOXYQUINOLINE 103028-31-5 C10H8BrNO
6-Chloro-1-tetralone 6-Chloro-1-tetralone 26673-31-4 C10H9ClO
8-BROMO-2-METHYL-QUINOLINE 8-BROMO-2-METHYL-QUINOLINE 61047-43-6 C10H8BrN
5,7-Dimethyl-8-hydroxyquinoline 5,7-Dimethyl-8-hydroxyquinoline 37873-29-3 C11H11NO
5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE 5,6,7,8-TETRAHYDROQUINOLIN-8-AMINE 298181-83-6 C9H12N2
4,6,8-TRIMETHYLQUINOLINE 4,6,8-TRIMETHYLQUINOLINE 88565-88-2 C12H13N
6-METHOXY-1,2,3,4-TETRAHYDROQUINOLINE 6-METHOXY-1,2,3,4-TETRAHYDROQUINOLINE 120-15-0 C10H13NO
1-METHYL-1,2,3,4-TETRAHYDRO-QUINOXALINE DIHYDROCHLORIDE 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOXALINE DIHYDROCHLORIDE 36438-97-8 C9H12N2
2-Methyl-1-(3-sulphonatopropyl)quinolinium 2-Methyl-1-(3-sulphonatopropyl)quinolinium 51583-69-8 C13H15NO3S
1,3-Dichloro-6-methoxyisoquinoline 1,3-Dichloro-6-methoxyisoquinoline 24623-39-0 C10H7Cl2NO
5-Aminoisoindolin-1-one 5-Aminoisoindolin-1-one 222036-66-0 C8H8N2O
QUINOLINE-2,4-DICARBOXYLIC ACID QUINOLINE-2,4-DICARBOXYLIC ACID 5323-57-9 C11H7NO4
5-HYDROXYMETHYLQUINOLINE 5-HYDROXYMETHYLQUINOLINE 16178-42-0 C10H9NO
2,8-DICHLORO-QUINOLINE-3-CARBALDEHYDE 2,8-DICHLORO-QUINOLINE-3-CARBALDEHYDE 144918-96-7 C10H5Cl2NO
4,5-DICHLORO-QUINOLINE 4,5-DICHLORO-QUINOLINE 21617-18-5 C9H5Cl2N
2,8-DICHLOROQUINOLINE 2,8-DICHLOROQUINOLINE 4470-83-1 C9H5Cl2N
4-METHOXY-2-QUINOLINECARBOXYLIC ACID 4-METHOXY-2-QUINOLINECARBOXYLIC ACID 15733-83-2 C11H9NO3
4-Amino-6-bromoquinoline 4-Amino-6-bromoquinoline 65340-73-0 C9H7BrN2
Pyrroloquinoline quinone disodium salt Pyrroloquinoline quinone disodium salt 122628-50-6 C14H4N2Na2O8
2-CHLORO-4-PHENYLQUINAZOLINE 2-CHLORO-4-PHENYLQUINAZOLINE 29874-83-7 C14H9ClN2
2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 851784-82-2 C15H17Cl2NO4
2,4-DICHLOROQUINOLINE 2,4-DICHLOROQUINOLINE 703-61-7 C9H5Cl2N
Pneumocandin B0 Pneumocandin B0 135575-42-7 C50H80N8O17
4-Fluoro-5-isoquinolinesulfonyl chloride hydrochloride (1:1) 4-Fluoro-5-isoquinolinesulfonyl chloride hydrochloride (1:1) 906820-08-4 C9H5Cl3FNO2S
1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4 -oxo-quinoline-3-carboxylic acid 1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4 -oxo-quinoline-3-carboxylic acid 354812-41-2 C21H24FN3O4
10-Hydroxybenzo[h]quinoline 10-Hydroxybenzo[h]quinoline 33155-90-7 C13H9NO
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 112811-72-0 C14H11F2NO4
6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 42923-77-3 C10H13NO
7-BROMO-ISOQUINOLIN-1-YLAMINE 7-BROMO-ISOQUINOLIN-1-YLAMINE 215453-53-5 C9H7BrN2
ALPHA,ALPHA,ALPHA-TRIBROMOQUINALDINE ALPHA,ALPHA,ALPHA-TRIBROMOQUINALDINE 613-53-6 C10H6Br3N
7-Quinolinecarboxylic acid 7-Quinolinecarboxylic acid 1078-30-4 C10H7NO2
5-bromoquinolin-8-ol 5-bromoquinolin-8-ol 1198-14-7 C9H6BrNO
8-Methoxyisoquinoline 8-Methoxyisoquinoline 1723-70-2 C10H9NO
4-HYDROXY-7-METHOXY-1H-QUINOLIN-2-ONE 4-HYDROXY-7-METHOXY-1H-QUINOLIN-2-ONE 27037-34-9 C10H9NO3
8-BROMO-2,4-DICHLOROQUINAZOLINE 8-BROMO-2,4-DICHLOROQUINAZOLINE 331647-05-3 C8H3BrCl2N2
lumateperone (Tosylate) lumateperone (Tosylate) 1187020-80-9 C31H36FN3O4S
7-(Difluoromethyl)Quinoline 7-(Difluoromethyl)Quinoline 1261728-71-5 C10H7F2N
6-METHYL-5-NITROQUINOLINE 6-METHYL-5-NITROQUINOLINE 23141-61-9 C10H8N2O2
4-(4-DIMETHYLAMINOSTYRYL)QUINOLINE 4-(4-DIMETHYLAMINOSTYRYL)QUINOLINE 897-55-2 C19H18N2
5,6,7,8-Tetrahydroquinaldine 5,6,7,8-Tetrahydroquinaldine 2617-98-3 C10H13N
5,6,7,8-TETRAHYDROQUINOLINONE-5 5,6,7,8-TETRAHYDROQUINOLINONE-5 53400-41-2 C9H9NO
3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol 3-(1,1-Difluorobut-3-en-1-yl)quinoxaline-2-ol 2146141-67-3 C12H10F2N2O
2,6-DICHLOROQUINOLINE 2,6-DICHLOROQUINOLINE 1810-72-6 C9H5Cl2N
7-METHOXY-ISOQUINOLINE 7-METHOXY-ISOQUINOLINE 39989-39-4 C10H9NO
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