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| | 4-chloro-6,7-dimethoxyquinoline Basic information |
| Product Name: | 4-chloro-6,7-dimethoxyquinoline | | Synonyms: | 6,7-DIMETHOXY-4-CHLOROQUINOLINE;4-CHLORO-6,7-DIMETHOXYQUINOLINE;4-Chloro-6,7-dimethoxyquioline;Quinoline, 4-chloro-6,7-dimethoxy-;4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9);Cabozantinib 4-Chloroquinoline Impurity;4-Chloro-6,7-dimethoxyquinoline >;oro-6,7-dimethoxyquinoL | | CAS: | 35654-56-9 | | MF: | C11H10ClNO2 | | MW: | 223.66 | | EINECS: | 676-028-8 | | Product Categories: | Quinoline&Isoquinoline;35654-56-9 | | Mol File: | 35654-56-9.mol |  |
| | 4-chloro-6,7-dimethoxyquinoline Chemical Properties |
| Melting point | 132.0 to 136.0 °C | | Boiling point | 325.2±37.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 3.95±0.30(Predicted) | | color | Pale Brown to Light Brown | | InChI | InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3 | | InChIKey | WRVHQEYBCDPZEU-UHFFFAOYSA-N | | SMILES | N1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1 | | CAS DataBase Reference | 35654-56-9(CAS DataBase Reference) |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45-24/25 | | RIDADR | UN2811 | | HazardClass | IRRITANT | | HS Code | 29334900 |
| | 4-chloro-6,7-dimethoxyquinoline Usage And Synthesis |
| Chemical Properties | Light brown powder | | Uses | 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents. | | Application | 4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis. | | Synthesis | With 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.
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| | 4-chloro-6,7-dimethoxyquinoline Preparation Products And Raw materials |
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