Antifungal Drugs

Since the 20th century, people have successively developed effective anti-fungal drugs such as griseofulvin. Flucytosine had been first introduced in the 1960s and its anti-fungal spectrum is limited to Candida and Cryptococcus, and is only used in combination with amphotericin B (AmB). A new era of the antifungal treatment is the development of the azole drug which reduces the toxicity and improves the antifungal effectiveness. The first drug, clotrimazole, was used only for the treatment of candidiasis infection of local mucosal and skin; the second, miconazole, is currently used only locally. It is not until the mid of 1970s when ketoconazole has been successfully developed before oral administration become effective against deep fungal infection. Ketoconazole has broad anti-bacterial spectrum and reduced toxicity, being considered to be a revolution during the development of antifungal drugs. However, severe patients can’t subject to oral administration for absorption. Moreover, the poor central nervous system penetration capability and poor antifungal activity as well as severe liver toxicity are limiting its clinical use.

In the late 1980s, people had successively developed itraconazole and fluconazole with more remarkable improved antimicrobial spectrum and bioavailability. Their emergence marked a new era of antifungal therapy. Even so, there are still no drugs that are absolutely fungicidal. In recent years, with increasing number of resistant strains, coupled with the limitations of drug toxicity, the treatment against fungal infection is facing many challenges. Currently the relatively promising drugs are drugs inhibiting the membrane ergosterol synthesis and interfering with cell wall 0-glucan synthesis, such as fluconazole, itraconazole and ciliary eumycetin. In addition, those old drugs with strong antibacterial effect but large toxicity are also subjecting to continuous improvement. Combination of two or more drugs is also the direction of antifungal therapy.

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Structure Chemical Name CAS MF
Luliconazole Luliconazole 187164-19-8 C14H9Cl2N3S2
Voriconazole Voriconazole 137234-62-9 C16H14F3N5O
Spectinomycin dihydrochloride pentahydrate Spectinomycin dihydrochloride pentahydrate 22189-32-8 C14H27ClN2O8
Biapenem Biapenem 120410-24-4 C15H18N4O4S
Torezolid Torezolid 856866-72-3 C17H15FN6O3
Miconazole nitrate Miconazole nitrate 22832-87-7 C18H15Cl4N3O4
Linezolid Linezolid 165800-03-3 C16H20FN3O4
Nisin Nisin 1414-45-5 C143H230N42O37S7
Fluconazole Fluconazole 86386-73-4 C13H12F2N6O
BAFILOMYCIN A1 BAFILOMYCIN A1 88899-55-2 C35H58O9
Amorolfine Amorolfine 78613-35-1 C21H35NO
5-Bromo-5-nitro-1,3-dioxane 5-Bromo-5-nitro-1,3-dioxane 30007-47-7 C4H6BrNO4
Itraconazole Itraconazole 84625-61-6 C35H38Cl2N8O4
Oxiconazole nitrate Oxiconazole nitrate 64211-46-7 C18H13Cl4N3O
cefsulodin sodium salt cefsulodin sodium salt 52152-93-9 C22H19N4O8S2.Na
Sertaconazole nitrate Sertaconazole nitrate 99592-32-2 C20H15Cl3N2OS
Fluorocytosine Fluorocytosine 2022-85-7 C4H4FN3O
Dihydrostreptomycin sulfate Dihydrostreptomycin sulfate 5490-27-7 C21H43N7O16S
Chlorphenesin Chlorphenesin 104-29-0 C9H11ClO3
SULCONAZOLE SULCONAZOLE 61318-90-9 C18H15Cl3N2S
GRAMICIDIN GRAMICIDIN 1405-97-6 C99H140N20O17
KP 103 KP 103 164650-44-6 C18H22F2N4O
IMIPENEM IMIPENEM 85960-17-4 C16H25N2O5S.C12H18N4O4.Na
Econazole nitrate Econazole nitrate 24169-02-6 C18H16Cl3N3O4
Butoconazole Butoconazole 64872-76-0 C19H17Cl3N2S
ANTIPAIN HYDROCHLORIDE DIHYDRATE ANTIPAIN HYDROCHLORIDE DIHYDRATE 37691-11-5 C27H44N10O6
BAFILOMYCIN B1 BAFILOMYCIN B1 88899-56-3 C44H65NO13
Tolnaftate Tolnaftate 2398-96-1 C19H17NOS
Naftifine Naftifine 65472-88-0 C21H21N
Lanoconazole Lanoconazole 101530-10-3 C14H10ClN3S2
IONOMYCIN IONOMYCIN 56092-81-0 C41H72O9
Cloxacillin-13C4 SodiuM Salt Cloxacillin-13C4 SodiuM Salt 642-78-4 C19H19ClN3NaO5S
Terbinafine Terbinafine 91161-71-6 C21H25N
Ozenoxacin Ozenoxacin 245765-41-7 C21H21N3O3
Miconazole Miconazole 22916-47-8 C18H14Cl4N2O
Octenidine Octenidine 71251-02-0 C36H62N4
SAPERCONAZOLE SAPERCONAZOLE 110588-57-3 C35H38F2N8O4
Tedizolid Phosphate Tedizolid Phosphate 856867-55-5 C17H16FN6O6P
Clotrimazole Clotrimazole 23593-75-1 C22H17ClN2
Ciclopirox Ciclopirox 29342-05-0 C12H17NO2
Taurolidine Taurolidine 19388-87-5 C7H16N4O4S2
Heptanoic acid Heptanoic acid 111-14-8 C7H14O2
Bifonazole Bifonazole 60628-96-8 C22H18N2
Butanedioicacid,2-hydroxy-,compd.with7-[(3S,5S)-3-amino-5-methyl-1-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylicacid Butanedioicacid,2-hydroxy-,compd.with7-[(3S,5S)-3-amino-5-methyl-1-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylicacid 951163-60-3 C20H25N3O4.C4H6O5
Butenafine hydrochloride Butenafine hydrochloride 101827-46-7 C23H27N.ClH
Fenticonazole nitrate Fenticonazole nitrate 73151-29-8 C24H21Cl2N3O4S
Sulfaquinoxaline sodium Sulfaquinoxaline sodium 967-80-6 C14H13N4NaO2S
Daptomycin Daptomycin 103060-53-3 C72H101N17O26
Ketoconazole Ketoconazole 65277-42-1 C26H28Cl2N4O4
PHLEOMYCIN PHLEOMYCIN 11006-33-0 C55H86N20O21S2
Oxytetracycline dihydrate Oxytetracycline dihydrate 6153-64-6 C22H26N2O10
CROCONAZOLE CROCONAZOLE 77175-51-0 C18H15ClN2O
Butoconazole nitrate Butoconazole nitrate 64872-77-1 C19H18Cl3N3O3S
Terbinafine Hydrochloride Terbinafine Hydrochloride 78628-80-5 C21H26ClN
Selenium sulfide Selenium sulfide 7446-34-6 SSe
Isoconazole Isoconazole 27523-40-6 C18H14Cl4N2O
Zinc heptylate Zinc heptylate C14H30O2Zn
Hexetidine Hexetidine 141-94-6 C21H45N3
Butenafine Butenafine 101828-21-1 C23H27N
Sertaconazole nitrate Sertaconazole nitrate 99592-39-9 C20H15Cl3N2OS.HNO3
Zinoconazole hydrochloride Zinoconazole hydrochloride 80168-44-1 C15H11Cl3N4S.ClH
CEPHALOSPORIN C ZINC SALT CEPHALOSPORIN C ZINC SALT 59143-60-1 C16H19N3O8SZn
CHRYSOMYCIN A CHRYSOMYCIN A 82196-88-1 C28H28O9
Siccanin Siccanin 22733-60-4 C22H30O3
2,4,6-TRIBROMO-3-METHYLPHENOL 2,4,6-TRIBROMO-3-METHYLPHENOL 4619-74-3 C7H5Br3O
CHRYSOMYCIN B CHRYSOMYCIN B 83852-56-6 C27H28O9
MICONAZOLE NITRATE MICONAZOLE NITRATE 75319-48-1 C18H15Cl4N3O4
HALOPROGIN HALOPROGIN 777-11-7 C9H4Cl3IO
1-[2-(2,4-Dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole 1-[2-(2,4-Dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole 72479-26-6 C24H20Cl2N2OS
Selenium sulfide Selenium sulfide 7488-56-4 S2Se
POLY-L-HISTIDINE POLY-L-HISTIDINE 61857-39-4 C6H9N3O2
GRAMICIDIN A GRAMICIDIN A 11029-61-1 C99H140N20O17
Econazole nitrate Econazole nitrate 68797-31-9 C18H16Cl3N3O4
Naftifine hydrochloride Naftifine hydrochloride 65473-14-5 C21H22ClN
SULCONAZOLE NITRATE FPC(CRM STANDARD) SULCONAZOLE NITRATE FPC(CRM STANDARD)
Lancovutide Lancovutide 1391-36-2 C89H125N23O25S3
Vagistat Vagistat 65899-73-2 C16H13Cl3N2OS
Brodimoprim Brodimoprim 56518-41-3 C13H15BrN4O2
Amorolfine Amorolfine 67467-83-8 C21H35NO
Selenium sulfide Selenium sulfide 56093-45-9 H4SSe
Econazole Econazole 27220-47-9 C18H15Cl3N2O
acrisorcin acrisorcin 7527-91-5 C13H10N2.C12H18O2
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