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| Product Name: | Amorolfine | | Synonyms: | AMOROLFINE;cis-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine;(2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;(2R,6S)-4-[3-(4-tert-amylphenyl)-2-methyl-propyl]-2,6-dimethyl-morpholine;Amorolfine/4-[3-[4-(11-Dimethylpropyl)phenyl]-2-methylpropyl]-26-dimethylmorpholine;Amorolfine Impurity 22;Voriconazole Impurity 97;Amorofen | | CAS: | 67467-83-8 | | MF: | C21H35NO | | MW: | 317.51 | | EINECS: | 1312995-182-4 | | Product Categories: | | | Mol File: | 67467-83-8.mol |  |
| | Amorolfine Chemical Properties |
| Boiling point | 407.1±33.0 °C(Predicted) | | density | 0.924±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Oil | | pka | 7.33±0.10(Predicted) | | color | Colourless |
| | Amorolfine Usage And Synthesis |
| Uses | Amorolfine is available for topical use in 0.25% cream and 5% nail lacquer formulation for the treatment of onychomycosis in European countries and Japan. However, amorolfine is not approved in the USA for such indications. The major advantage of this new antimycotic drug presumably lies in its potential for use as 5% nail lacquer in the treatment of onychomycosis caused by dermatophytes and Candida spp. | | Side effects | Topical application of amorolfine (5% nail lacquer and 0.25% cream) is generally well tolerated, with up to 5% of patients reporting minor symptoms. In patients using the nail lacquer, these events included burning, itching, redness, and local pain, which were toleratable and confined to the application site. Adverse effects of scaling, weeping, blistering, and edema have also been described for the cream formulation. | | Uses | Antimycotic. | | Uses | Amorolfine is a novel antifungal agent used in the treatment of cutaneous fungal disease. | | Brand name | Loceryl (Hoffmann-LaRoche). |
| | Amorolfine Preparation Products And Raw materials |
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