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| | Amorolfine Basic information |
| Product Name: | Amorolfine | | Synonyms: | (+/-)-cis-2,6-dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine;SYLIMARIN;4-(3-(4-(1,1-Dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine;Morpholine, 4-3-4-(1,1-dimethylpropyl)phenyl-2-methylpropyl-2,6-dimethyl-, (2R,6S)-rel-;Loceryl;Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, cis-;Ro 14-4767;Ro 14-4767/000 | | CAS: | 78613-35-1 | | MF: | C21H35NO | | MW: | 317.51 | | EINECS: | | | Product Categories: | | | Mol File: | 78613-35-1.mol |  |
| | Amorolfine Chemical Properties |
| Boiling point | bp0.1 120° | | density | 0.924±0.06 g/cm3(Predicted) | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Oil | | pka | 7.33±0.10(Predicted) | | color | Colourless | | CAS DataBase Reference | 78613-35-1(CAS DataBase Reference) |
| | Amorolfine Usage And Synthesis |
| Uses | Amorolfine is a novel antifungal agent used in the treatment of cutaneous fungal disease. | | Definition | ChEBI: A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action
f squalene monooxygenase, Delta14 reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections. | | Clinical Use | Amorolfine is the only drug in this class that is employed clinically in the treatment of human fungal infections. Amorolfine is not currently available in the United States, but it is marketed in Europe and Asia for the topical treatment of dermatophytic infections. |
| | Amorolfine Preparation Products And Raw materials |
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