Gastrointestinal antispasmodic drugs

Gastrointestinal antispasmodic drugs are mainly M receptor blockers, briefly referred to as anticholinergics, including belladonna alkaloids and their derivatives and artificial synthetic substitutes. For example: atropine, anisodamine, scopolamine, belladonna, trimebutine, and propanthine.

Mechanism These drugs function mainly through weakening the peristalsis function of the gastrointestinal tract, causing relaxation of the esophagus and gastrointestinal sphincter, thereby slowing down the stomach emptying and intestinal transport, weakening the gallbladder contraction and reducing the gallbladder pressure as well as weakening the colon peristalsis and slowing down the transport of colon contents.

Clinical anticholinergic drugs has atropine be the typical representative, mainly used for treating gastrointestinal dysfunction, relieving visceral colic, treating acute microcirculation and various kind of toxic shock and poisoning rescue and so on.

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Structure Chemical Name CAS MF
BENACTYZINE HYDROCHLORIDE BENACTYZINE HYDROCHLORIDE 57-37-4 C20H26ClNO3
Valethamate bromide Valethamate bromide 90-22-2 C19H32BrNO2
L-Hyoscyamine L-Hyoscyamine 101-31-5 C17H23NO3
Swertiamarine Swertiamarine 17388-39-5 C16H22O10
Tizanidine hydrochloride Tizanidine hydrochloride 64461-82-1 C9H9Cl2N5S
Scopolamine butylbromide Scopolamine butylbromide 149-64-4 C21H30BrNO4
Drotaverine hydrochloride Drotaverine hydrochloride 985-12-6 C24H32ClNO4
Tizanidine Tizanidine 51322-75-9 C9H8ClN5S
Glycopyrrolate Glycopyrrolate 596-51-0 C19H28BrNO3-
Drotaverin hydrochloride Drotaverin hydrochloride 14009-24-6 C24H31NO4
Propantheline bromide Propantheline bromide 50-34-0 C23H30BrNO3
Adiphenine hydrochloride Adiphenine hydrochloride 50-42-0 C20H25NO2.ClH
METHSCOPOLAMINE BROMIDE METHSCOPOLAMINE BROMIDE 155-41-9 C18H24BrNO4
Mebeverine hydrochloride Mebeverine hydrochloride 2753-45-9 C25H35NO5.ClH
Gefarnate Gefarnate 51-77-4 C27H44O2
ISOCORYDINE HYDROCHLORIDE ISOCORYDINE HYDROCHLORIDE 13552-72-2 C20H24ClNO4
Oxyphenonium bromide Oxyphenonium bromide 50-10-2 C21H34BrNO3
MEBEVERINE MEBEVERINE 3625-06-7 C25H35NO5
DipenineBromide DipenineBromide
octamylamine octamylamine 502-59-0 C40H88N
MethylbenactyziumBromide MethylbenactyziumBromide C21H28BrNO3
THYROGLOBULIN, HUMAN THYROGLOBULIN, HUMAN 9010-34-8
ATROPINE METHYL BROMIDE ATROPINE METHYL BROMIDE 2870-71-5 C18H26BrNO3
isometheptene isometheptene 503-01-5 C9H19N
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