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| | Oxyphenonium bromide Basic information |
| Product Name: | Oxyphenonium bromide | | Synonyms: | ba-5473;c5473;diethyl(2-hydroxyethyl)methylammoniumbromidealpha-phenylcyclohexaneglycolat;oxifenon;oxyfenon;oxyphenon;2-[(Cyclohexylhydroxyphenylacetyl)oxy]-N,N,-diethyl-N-methylethylammonium bromide;Oxyphenonium | | CAS: | 50-10-2 | | MF: | C21H34BrNO3 | | MW: | 428.4 | | EINECS: | 200-010-7 | | Product Categories: | ANTRENYL | | Mol File: | 50-10-2.mol |  |
| | Oxyphenonium bromide Chemical Properties |
| Melting point | 189-194° from ethyl acetate + alc | | density | 1.2584 (rough estimate) | | refractive index | 1.6200 (estimate) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | A solid | | color | White to Off-White |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | BP7625000 | | Toxicity | LD50 orl-rat: 995 mg/kg JPETAB 108,292,53 |
| | Oxyphenonium bromide Usage And Synthesis |
| Originator | A-Spasm ,Acme Laboratories Ltd. | | Uses | anticholinergic, anticonvulsant | | Manufacturing Process | 1 mol cycloxehylhydroxyphenylacetic acid methyl ester was mixed with 1 mol 2-diethylaminoethanol in presence of 1 mol sodium methylate to give cycloxehylhydroxyphenylacetic acid 2-diethylamino-ethyl ester.
5 parts by weight of it was dissolved in 50 volumes glacial acetic acid and a gaseous methyl bromide was introduced. The mixture was heated to about 50°C and crystallization of cycloxehylhydroxyphenylacetic acid diethylaminoethyl ester methyl bromide has shortly after begun. On cooling the crystals was filtered off and recrystallized from mixture of ethyl acetate ant a little ethanol to give the oxyphenonium bromide. MP: 189°-191°C.
| | Brand name | Antrenyl (Novartis). | | Therapeutic Function | Anticholinergic, Spasmolytic | | Safety Profile | Poison by ingestion, intramuscular, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: change in heart rate. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Brí. |
| | Oxyphenonium bromide Preparation Products And Raw materials |
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