BENACTYZINE HYDROCHLORIDE

BENACTYZINE HYDROCHLORIDE Basic information
Product Name:BENACTYZINE HYDROCHLORIDE
Synonyms:2-(diethylamino)-ethanobenzilatehydrochloride;2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid;Benactyzine HCL;BENACTYZINE HYDROCHLORIDE 98+%;BENACTYCIN HYDROCHLORIDE;2-(Diethylamino)ethyl benzilate hydrochloride, Benactyzine, α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester;Amizyl;2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [czech]
CAS:57-37-4
MF:C20H26ClNO3
MW:363.88
EINECS:200-324-4
Product Categories:Inhibitors;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:57-37-4.mol
BENACTYZINE HYDROCHLORIDE Structure
BENACTYZINE HYDROCHLORIDE Chemical Properties
Melting point 177-179 °C(lit.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Slightly)
form Solid
color Crystals from Me2CO
Merck 14,1029
CAS DataBase Reference57-37-4(CAS DataBase Reference)
EPA Substance Registry SystemBenzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (57-37-4)
Safety Information
Hazard Codes T
Risk Statements 23/24/25
Safety Statements 36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DD2800000
HS Code 2922.50.4000
HazardClass 6.1(b)
PackingGroup III
ToxicityLD50 orl-rat: 184 mg/kg TXAPA9 1,42,59
MSDS Information
ProviderLanguage
SigmaAldrich English
BENACTYZINE HYDROCHLORIDE Usage And Synthesis
OriginatorSuavitil,Merck Sharp and Dohme,US,1957
UsesBenactyzine Hydrochloride is an antagonist of acetylcholine in the central and peripheral nervous system. Benactyzine Hydrochloride is used as an antispasmodic.
Manufacturing Process114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part of metallic sodium were placed in a flask attached to a total-reflux variable take-off fractionating column. The pressure was reduced to 100 mm and heat was applied by an oil bath the temperature of which was slowly raised to 90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C). When the distillation of the ethanol became slow, the bath temperature was raised to 120°C. When the vapor temperature indicated distillation of the amino alcohol the take off valve was closed and the mixture was refluxed for one hour. At the end of this period the vapor temperature had dropped and two more parts of ethanol were distilled, The remaining aminoalcohol was slowly distilled for three hours. The pressure was then reduced to 20 mm and the remainder of the aminoalcohol distilled at 66°C. During the reaction the color of the solution changed from yellow to deep red. The residue was dissolved in 500 parts of ether, washed once with dilute brine, and three times with water, dried over sodium sulfate and finally dried over calcium sulfate. 500 parts of a saturated solution of HCl in absolute ether was added and the resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a slight excess and the precipitate again filtered. The combined precipitates were washed with cold acetone. The 106 parts of product was purified by recrystallization from acetone as fine white crystals which melt at 177°- 178°C.
Therapeutic FunctionTranquilizer; Anticholinergic
Safety ProfilePoison by ingestion, intraperitoneal, subcutaneous, intradermal, and intravenous routes. Human systemic effects by ingestion of very small amounts: toxic psychosis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO, and HCl
BENACTYZINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materialsEthylamine-->Benzilic acid-->Hydrochloric acid-->Sodium-->ETHYL BENZILATE
Rimantadine hydrochloride RIMANTADINE HCL USP(CRM STANDARD) Benazepril hydrochloride Ethambutol Cetirizine hydrochloride ETHYL BENZILATE Benactyzine N-METHYL L-QNB, [N-METHYL-3H]- BENACTYZINE HYDROCHLORIDE Benzilic acid 2,2-Diphenyl-2-methoxyacetic acid (2-(N-ethyl-N-pentylamino)ethyl) est er hydrochloride Piperilate hydrochloride 2,2-Diphenyl-2-ethoxyacetic acid (2-(N-sec-butyl-N-ethylamino)ethyl) e ster hydrochloride Ethylamine hydrochloride Acetic acid, 2,2-diphenyl-2-ethoxy-, (2-(N-ethyl-N-propylamino)ethyl) ester, hydrochloride 2,2-Diphenyl-2-methoxyacetic acid (1-ethyl-3-piperidyl) ester hydrochl oride Methylbenactyzine bromide

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