Cholinergic drugs

The drugs which have similar role as acetylcholine are collectively referred to cholinergic drugs. According to its role in different principles, they can be divided into cholinergic like receptor agonists and cholinesterase inhibitors.
Choline receptor agonists can directly bind to the cholinergic receptor, resulting in a similar effect to acetylcholine.
Acetylcholine is a cholinergic neurotransmitter that activates the M-cholinergic receptor and the N-cholinergic receptor. When the M receptor is agitated, its effect often manifest as heart suppression, vasodilation, visceral smooth muscle contraction, sphincter relaxation and increased glandular secretion. These effects are called M-like effect. When the N receptor is agitated, its effect often manifest as ganglion excitement, skeletal muscle contraction and these effects are called N-like effect.
Because of the instability of chemical nature of acetylcholine in human body, it could quickly loose its effect by cholinesterase hydrolysis. It has been used widely so there is not a high selectivity. So it has no clinical value. Some compounds which has the similar chemical structure as acetylcholine are more stable and has high selectivity. So they has wide clinical applications.
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Structure Chemical Name CAS MF
Naphazoline hydrochloride Naphazoline hydrochloride 550-99-2 C14H14N2.ClH
Choline chloride Choline chloride 67-48-1 C5H14ClNO
Atropine sulfate monohydrate Atropine sulfate monohydrate 5908-99-6 C17H25NO7S
Choline bitartrate Choline bitartrate 87-67-2 C9H19NO7
Galantamine Hydrobromide Galantamine Hydrobromide 1953-04-4 C17H22BrNO3
(-)-Huperzine A (-)-Huperzine A 102518-79-6 C15H18N2O
Acetylcholine chloride Acetylcholine chloride 60-31-1 C7H16ClNO2
Scopolamine hydrobromide Scopolamine hydrobromide 114-49-8 C17H21NO4.BrH
Choline glycerophosphate Choline glycerophosphate 28319-77-9 C8H20NO6P
Neostigmine Methyl Sulfate Neostigmine Methyl Sulfate 51-60-5 C12H19N2O2.CH3O4S
PHYSOSTIGMINE PHYSOSTIGMINE 57-47-6 C15H21N3O2
Neostigmine bromide Neostigmine bromide 114-80-7 C12H19BrN2O2
METHACHOLINE CHLORIDE METHACHOLINE CHLORIDE 62-51-1 C8H18ClNO2
Choline hydroxide Choline hydroxide 123-41-1 C5H15NO2
HOMATROPINE METHYL BROMIDE HOMATROPINE METHYL BROMIDE 80-49-9 C17H24BrNO3
Mestinon Mestinon 101-26-8 C9H13BrN2O2
PHYSOSTIGMINE SALICYLATE PHYSOSTIGMINE SALICYLATE 57-64-7 C22H27N3O5
Atropine Atropine 51-55-8 C17H23NO3
ANISODINE ANISODINE C17H21NO5
Huperzine A Huperzine A 120786-18-7 C15H18N2O
Acetylcholine Acetylcholine 51-84-3 C7H16NO2+
CHOLINE CHOLINE 62-49-7 C5H14NO+
Homatropine Hydrobromide Homatropine Hydrobromide 51-56-9 C16H22BrNO3
2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride 522-48-5 C13H17ClN2
Carbachol Carbachol 51-83-2 C6H15N2O2.Cl
PILOCARPINE PILOCARPINE 92-13-7 C11H16N2O2
Naphazoline Naphazoline 835-31-4 C14H14N2
Pilocarpine nitrate Pilocarpine nitrate 148-72-1 C11H17N3O5
GALANTHAMINONE GALANTHAMINONE 510-77-0 C17H19NO3
ambenonium chloride ambenonium chloride 115-79-7 C28H42Cl2N4O2.2Cl
GALANTHAMINE HYDROBROMIDE GALANTHAMINE HYDROBROMIDE 69353-21-5 C17H22BrNO3
Tetryzoline Tetryzoline 84-22-0 C13H16N2
BENZETIMIDE BENZETIMIDE 21888-98-2 C23H26N2O2
Anisodamine Anisodamine 17659-49-3 C17H23NO4
Demecarium bromide Demecarium bromide 56-94-0 C32H52Br2N4O4
Anisodine hydrobromide Anisodine hydrobromide 76822-34-9 C17H21NO5.BrH
Etybenzatropine Etybenzatropine 524-83-4 C22H27NO
HOMATROPINE HOMATROPINE 87-00-3 C16H21NO3
HYOSCINE N BUTYL BROMIDE BP HYOSCINE N BUTYL BROMIDE BP
Dihydrogalanthamine Dihydrogalanthamine 21133-52-8 C17H23NO3
Atropine sulfate Atropine sulfate 55-48-1 2C17H23NO3.H2O4S
ANISODAMINE HYDROBROMIDE ANISODAMINE HYDROBROMIDE 55449-49-5 C7H10BrNO
Cuscohygrine Cuscohygrine 454-14-8 C13H24N2O
ANISODAMINE ANISODAMINE 55869-99-3 C17H23NO4
OLEYLOXYETHYL PHOSPHORYLCHOLINE OLEYLOXYETHYL PHOSPHORYLCHOLINE 84601-19-4 C25H52NO5P
Scopolamine Scopolamine 51-34-3 C17H21NO4
Racanisodamine Racanisodamine
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