Choline glycerophosphate

Choline glycerophosphate Basic information

Product Name:	Choline glycerophosphate
Synonyms:	L-A-GLYCEROPHOSPHOCHOLINE;2-(((2,3-Dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium inner salt;2,3-Dihydroxypropyl 2-trimethylazaniumylethyl phosphate;L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE(ALPHA-GPC);L-α-Glycerophoshorylchoilne;L-á-Glycerophosphorylcholine (from egg yolk);L-alpha-glycerol phosphorylcholine;L-α-Glycerophosphorylcholine inner salt
CAS:	28319-77-9
MF:	C8H20NO6P
MW:	257.22
EINECS:	248-962-2
Product Categories:	GPC;Smart drug;Activity;Enzyme Substrates;Activity Other;pharmaceutical ingredients;28319-77-9
Mol File:	28319-77-9.mol

Choline glycerophosphate Chemical Properties

Melting point	142.5-143°
alpha	D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8)
Boiling point	480℃[at 101 325 Pa]
vapor pressure	0Pa at 25℃
Fp	11 °C
storage temp.	-20°C
solubility	DMSO (Slightly, Heated, Sonicated), Methanol (Sparingly), Water (Sparingly)
form	solid
color	White to Off-White
Water Solubility	1000g/L at 25℃
Stability:	Very Hygroscopic
InChI	InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3
InChIKey	SUHOQUVVVLNYQR-SBYBRXNCNA-N
SMILES	P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO \|&1:12,r\|
LogP	-5.15 at 25℃
CAS DataBase Reference	28319-77-9(CAS DataBase Reference)

Safety Information

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25
Safety Statements	16-36/37-45-24/25
RIDADR	UN 1230 3/PG 2
WGK Germany	2
RTECS	KH2775000
HS Code	29239000

MSDS Information

Provider	Language
Choline glycerophosphate	English
SigmaAldrich	English

Choline glycerophosphate Usage And Synthesis

Description	Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.
Chemical Properties	White waxy solid
Originator	Sandoz; Italfarmaco (Italy)
Uses	sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
Uses	L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids.
Definition	ChEBI: A member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells.
Brand name	Delecit
General Description	L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.
Flammability and Explosibility	Notclassified
Biochem/physiol Actions	Increases inositol phosphate formation.

Choline glycerophosphate Preparation Products And Raw materials

Preparation Products

1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE-->1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE-->1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE-->L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, CAPROYL-->L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROYL

H-GLY-MET-OH tert-Butyl glycinate CYCLAZOSIN HYDROCHLORIDE Acetylcholine 1-O-HEXADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE Citiolone 1-MYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROYL L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL Β-GLYCEROPHOSPHATE triphosphate 1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Choline Carbonate phosphate POPC 1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE OLEYLOXYETHYL PHOSPHORYLCHOLINE

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