HOMATROPINE METHYL BROMIDE

HOMATROPINE METHYL BROMIDE Basic information
Product Name:HOMATROPINE METHYL BROMIDE
Synonyms:methylhomatropine;methylhomatropinebromide;Homotropine methylbromide;8-Methylhomatropininium;Homatropine methyl;N-Methylhomatropinium;D02070;Equipin
CAS:80-49-9
MF:C17H24BrNO3
MW:370.28
EINECS:201-284-0
Product Categories:Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;EQUIPIN;Other APIs;Alkaloids;Biochemistry;Tropane Alkaloids
Mol File:80-49-9.mol
HOMATROPINE METHYL BROMIDE Structure
HOMATROPINE METHYL BROMIDE Chemical Properties
Melting point 192°C
storage temp. -20°C Freezer
solubility Freely soluble in water, soluble in ethanol 96 per cent
form neat
color White to Off-White
Merck 14,4730
CAS DataBase Reference80-49-9(CAS DataBase Reference)
EPA Substance Registry SystemHomatropine methylbromide (80-49-9)
Safety Information
Risk Statements 20/21/22
Safety Statements 22-26-36
RIDADR 1544
WGK Germany 3
RTECS MS9000000
HazardClass 6.1
PackingGroup III
HS Code 29399990
ToxicityLD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede)
MSDS Information
HOMATROPINE METHYL BROMIDE Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder or colourless crystals
UsesHomatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. Methylhomatropine is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Methylhomatropine does not cross the blood–brain barrier. Methylhomatropine is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.
Usesanticholinergic (opthalmic)
Brand nameEquipin (Mission); Homapin (Mission).
General DescriptionHomatropinemethylbromide, 3 -hydroxy-8-methyl-1 H,5 H-tropaniumbromide mandelate (Novatropine, Mesopin), occurs as a bitter,white, odorless powder and is affected by light. The compoundis readily soluble in water and alcohol but insoluble inether. The pH of a 1% solution is 5.9 and that of a 10% solutionis 4.5. Although a solution of the compound yields a precipitatewith alkaloidal reagents, such as mercuric potassiumiodide test solution, addition of alkali hydroxides or carbonatesdoes not cause the precipitate that occurs with nonquaternarynitrogen salts (e.g., atropine, homatropine).
Clinical UseHomatropine methylbromide is transported poorly acrossthe blood-brain barrier because of its quaternary ammoniumgroup and, therefore, has far fewer stimulant properties thanatropine. It does have all the characteristic peripheralparasympathetic depressant properties of atropine and isused to reduce oversecretion and to relieve GI spasms.
HOMATROPINE METHYL BROMIDE Preparation Products And Raw materials
N-BUTYL MANDELATE (S)-2-Pyrrolidin-2-yl-ethanol Homatropine Hydrobromide (S)-2-ETHYLPIPERIDINE pyrrolidine-2-ethanol AMMONIUM M AND ELATE (+)-HOMATROPINE METHYLBROMIDE HEXYL LACTATE 1-Methyl-2-pyrrolidineethanol 1-METHYLPIPERIDIN-4-OL HYDROBROMIDE 8-METHYL-8-AZABICYCLO[3.2.1]OCTANE PETIOLE ETHYL MANDELATE FEMA 3457 2,6-DIMETHYL-4-HYDROXYPIPERIDINE HOMATROPINE METHYL BROMIDE N-CYCLOHEPTYL-N-METHYLAMINE 6-DIMETHYLAMINO-1-HEXANOL

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