Choline hydroxide

Choline hydroxide Basic information
Description References
Product Name:Choline hydroxide
Synonyms:(2-HYDROXYETHYL)TRIMETHYLAMMONIUM HYDROXIDE;CHOLINE HYDROXIDE;CHOLINE;CHOLINE BASE;2-hydroxy-n,n,n-trimethyl-ethanaminiuhydroxide;bursine;choline,solution;fagine
CAS:123-41-1
MF:C5H15NO2
MW:121.18
EINECS:204-625-1
Product Categories:Vitamin Related Compounds;Ammonium Hydroxides (Quaternary);Biochemistry;Quaternary Ammonium Compounds;Vitamins;Chemical Synthesis;Quarternary ammonium bases;Organic Bases;Synthetic Reagents
Mol File:123-41-1.mol
Choline hydroxide Structure
Choline hydroxide Chemical Properties
Melting point 236~239℃
density 1.09 g/mL at 20 °C
vapor pressure 28.284hPa at 25℃
refractive index n20/D 1.4304
Fp 92 °F
storage temp. Inert atmosphere,2-8°C
form Granular Powder
pka13.9(at 25℃)
color White
Water Solubility miscible
Merck 14,2204
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKeyKIZQNNOULOCVDM-UHFFFAOYSA-M
LogP-2.25 at 25℃
CAS DataBase Reference123-41-1(CAS DataBase Reference)
EPA Substance Registry SystemEthanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (123-41-1)
Safety Information
Hazard Codes C,T
Risk Statements 34-35-43-39/23/24/25-23/24/25-10-R35
Safety Statements 26-36/37/39-45-S45-S36/37/39-S26
RIDADR UN 3286 3/PG 2
WGK Germany 1
RTECS GA4025500
8-9-23
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29231000
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Choline hydroxide Usage And Synthesis
DescriptionCholine hydroxide or choline base is also known as 2-hydroxyl ethyl trimethyl ammonium hydroxide. It is a strong yet organic base.
Choline hydroxide is primarily used to produce other choline salts, which could be used in nutraceuticals, baby food, etc.  Choline hydroxide can be used as phase transfer catalysts which carry the hydroxide ion into organic systems. It is used as an ingredient in cleaning and developer formulations in the electronics and printed circuit board industry and in paint stripping formulations. It can also be used as corrosion inhibitor, for the H2S removal from gas streams. Furthermore, it is used as the cleaning and degreasing agent in the metal industry.
References[1] Patent US20160068476: Process for choline hydroxide
[2] https://en.wikipedia.org/wiki/Choline
Chemical Propertiesclear light yellow viscous solution
UsesCholine hydroxide is used as a precursor molecule for the neurotransmitter acetylcholine, it is involved in several functions including muscle and memory muscle control. It was used as a basic catalyst for aldol condensation reactions.
UsesCholine hydroxide solution has been used in the synthesis of choline hexafluoroacetylacetonate that can be used as an extractant along with bis-(trifluoromethylsulfonyl)imide ionic liquid for the homogeneous liquid-liquid extraction of neodymium(III).
DefinitionAn amino alcohol,CH2OHCH2N(CH3)3OH. It occurswidely in living organisms as aconstituent of certain types ofphospholipids– the lecithins andsphingomyelins– and in the neurotransmitteracetylcholine. It issometimes classified as a memberof the vitamin B complex.
Flammability and ExplosibilityNonflammable
choline,tartrate(1:1)sal Lecithin Citicoline sodium Ammonium hydroxide TETRAETHANOL AMMONIUM HYDROXIDE Tetraethylammonium bromide Benzyltrimethylammonium hydroxide Tetraethylammonium hydroxide 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE Trimethylaminium 2-(2-Aminoethylamino)ethanol benzyldimethyl[2-[2-[4-(1,1,3,3-tetramethylbutyl)tolyloxy]ethoxy]ethyl]ammonium hydroxide Hydroxyethyl Cellulose Tetramethylammonium hydroxide pentahydrate 2-(METHYLSULFONYL)ETHANOL Sodium hydroxide Sodium isethionate Aluminum hydroxide Choline Hydroxide Solution

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