Antineoplastic agents

Antineoplastic is a class of medicine to restrain or kill tumor cells in the body. It plays an important role in comprehensive cancer treatment, particularly for disseminated tumor and leukemia that cannot be treated with surgery. Most current antineoplastics work by inhibiting DNA or RNA synthesis, or even damaging the structure of DNA. Antineoplastics can be divided into CCNSA (Cell cycle nonspecific drug) and CCSA (Cell Cycle Specific agents) according to their different effect on tumor cells in different stages of generation cycles. Both of them have a killing effect on bone marrow hematopoietic stem cells and other cells with a short growth cycle, as well as an inhibiting effect on the body's immune response.

Antineoplastic has a wide variety of drugs, which can be divided into following categories:
alkylating agents, such as cyclophosphamide, Glyciphosphoramide, thiotepa, etc.;
antimetabolites, such as methotrexate, mercaptopurine, fluorouracil, hydroxyurea, etc.;
antibiotics, such as dactinomycin, mitomycin C, bleomycin, etc.;
hormones, such as prednisone, testosterone propionate, diethylstilbestrol, etc.;
some botanical drugs, such as Vinblastine, camptothecin, colchicine, etc.;
and other classes, such as procarbazine, propylene imine, Yishuangmalin, etc.
With their enormous diversity and different mechanisms, antineoplastics must be carefully selected for clinical application.

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Structure Chemical Name CAS MF
brotianide brotianide 23233-88-7 C15H10Br2ClNO2S
Bleomycin hydrochloride Bleomycin hydrochloride 67763-87-5 C50H71N16O21S2R.x(HCl)
Predmustine Predmustine
Antienite Antienite 5029-05-0 C9H8N2S2
Teniloxazine Teniloxazine 62473-79-4 C16H19NO2S
CHROMOMYCIN A3 CHROMOMYCIN A3 7059-24-7 C57H82O26
Meisoindigo Meisoindigo 97207-47-1 C17H12N2O2
Ancitabine Ancitabine 31698-14-3 C9H11N3O4
2-(Aminomethyl)cyclobutyl]methanamine 2-hydroxypropanoic acid platinum salt 2-(Aminomethyl)cyclobutyl]methanamine 2-hydroxypropanoic acid platinum salt 131374-93-1 C9H18N2O3Pt+2
iMatinib related substance B iMatinib related substance B 571186-93-1 C29H31N7O3
2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- 21416-87-5 C11H16N4O4
SodiuM DeMethylcantharidate SodiuM DeMethylcantharidate 33054-59-0 C8H11NaO5
BendaMustine IMpurity C   BendaMustine IMpurity C   1313020-25-5 C19H27Cl2N3O2
DAUNOMYCINOL DAUNOMYCINOL 28008-55-1 C27H31NO10
FLUOROURACIL;FLURACIL FLUOROURACIL;FLURACIL C8H5FN4O4
elmustine elmustine 60784-46-5 C5H10ClN3O3
4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline 183321-84-8 C20H19N3O4
Ambamustine Ambamustine 85754-59-2 C29H39Cl2FN4O4S
EMITEFUR EMITEFUR 110690-43-2 C28H19FN4O8
Ditiomustine Ditiomustine 82599-22-2 C10H18Cl2N6O4S2
Enpromate Enpromate 10087-89-5 C22H23NO2
Neptamustine Neptamustine 73105-03-0 C8H16ClN3O2
GLYFOSFIN GLYFOSFIN
motexafin gadolinium motexafin gadolinium 156436-89-4 C52H74GdN5O15
IMatinib Meta-Methyl-piperazine IMatinib Meta-Methyl-piperazine
NITROCAPHANE NITROCAPHANE C14H19Cl2N3O4
Methyl cantharidimide Methyl cantharidimide
tenylidone tenylidone 893-01-6 C16H14OS2
Sorafenib Tosylate Sorafenib Tosylate C4H7NO4
Ecomustine Ecomustine 98383-18-7 C10H18ClN3O6
Semustine Semustine 13909-09-6 C10H18ClN3O2
Streptonigrin Streptonigrin 3930-19-6 C25H22N4O8
ACLARUBICIN HYDROCHLORIDE ACLARUBICIN HYDROCHLORIDE 75443-99-1 C42H54ClNO15
ZENIPLATIN ZENIPLATIN 111490-36-9 C11H20N2O6Pt
Bisantrene Bisantrene 78186-34-2 C22H22N8
Tauromustine Tauromustine 85977-49-7 C7H15ClN4O4S
IMatinib Para-diaMinoMethylbenzene IMatinib Para-diaMinoMethylbenzene 1026753-54-7 C29H31N7O
URACIL  MUSTARD URACIL MUSTARD 66-75-1 C8H11Cl2N3O2
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL 488-41-5 C6H12Br2O4
Tallimustine Tallimustine 115308-98-0 C32H38Cl2N10O4
Aclarubicin Aclarubicin 57576-44-0 C42H53NO15
BendaMustine IMpurity B BendaMustine IMpurity B
Ranimustine Ranimustine 58994-96-0 C10H18ClN3O7
carboquone carboquone 24279-91-2 C15H19N3O5
Bleomycin A5 Bleomycin A5 11116-32-8 C57H89N19O21S2
Betahistine Hydrochloride Betahistine Hydrochloride 15430-48-5 C8H13ClN2
Bofumustine Bofumustine 55102-44-8 C18H21ClN4O9
4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 590424-04-7 C18H31N3O3
4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile 236750-65-5 C13H16N2O6
BendaMustine IMpurity A   BendaMustine IMpurity A   109882-26-0 Br-
DESACETYLVINBLASTINEAMIDE DESACETYLVINBLASTINEAMIDE 53643-48-4 C43H55N5O7
TEGAFUR TEGAFUR 37076-68-9 C8H9FN2O3
Spiromustine Spiromustine 56605-16-4 C14H23Cl2N3O2
Tenilapine Tenilapine 82650-83-7
Methoxymerphalan Methoxymerphalan
Diazomycin B Diazomycin B 7644-67-9 C17H23N7O8
(1alpha,2beta,4beta)-1-methyl-2,4-bis(methylvinyl)-1-vinylcyclohexane (1alpha,2beta,4beta)-1-methyl-2,4-bis(methylvinyl)-1-vinylcyclohexane 33880-83-0 C15H24
Dianhydrodulcitol Dianhydrodulcitol
Solaziquone Solaziquone
PEPLOMYCIN PEPLOMYCIN 68247-85-8 C61H88N18O21S2
Hydroxyl camptothecine Hydroxyl camptothecine
epipropidine epipropidine 5696-17-3 C16H28N2O2
OCAPHANE OCAPHANE
Mechlorethaminoxide Mechlorethaminoxide
IRISQUINONE IRISQUINONE 56495-82-0 C24H38O3
SulfomercaprineSodium SulfomercaprineSodium
mannomustine mannomustine 576-68-1 C10H22Cl2N2O4
mitopodozide mitopodozide 1508-45-8 C24H30N2O8
HARRINGTONINE(P) HARRINGTONINE(P)
Mitoguazone Mitoguazone
Colchiceinamide Colchiceinamide
TRIETHYLENEMELAMINE TRIETHYLENEMELAMINE 51-18-3 C9H12N6
INOSINE, PERIODATE OXIDIZED INOSINE, PERIODATE OXIDIZED 23590-99-0 C10H10N4O5
trisethyleneiminoquinone trisethyleneiminoquinone 68-76-8 C12H13N3O2
ACTINOMYCIN C ACTINOMYCIN C 8052-16-2
PODOPHYLLUM BP PODOPHYLLUM BP
Formylmerphalan Formylmerphalan
BETAMERPHALAN BETAMERPHALAN
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