ChemicalBook Product Catalog API Antineoplastic agents Other antineoplastic Drugs 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-

2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-

2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Basic information
Product Name:2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-
Synonyms:2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-;(±)-1，2-Bis(3，5-diox-opiperazinyl)propane;Razoxane;ICRF;ICRF-159;Eucardion;ICI-59118;ICRF-187
CAS:21416-87-5
MF:C11H16N4O4
MW:268.27
EINECS:
Product Categories:
Mol File:21416-87-5.mol
2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Structure
2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Chemical Properties
Melting point 233.5°C
Boiling point 411.43°C (rough estimate)
density 1.2576 (rough estimate)
refractive index 1.6081 (estimate)
storage temp. Refrigerator
solubility DMSO (Slightly)
form Solid
color White
Safety Information
MSDS Information
2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Usage And Synthesis
UsesRazoxane is an inhibitor of Topo II.
DefinitionChEBI: Razoxane is a N-alkylpiperazine.
Safety ProfileSuspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: nausea, thrombocytopenia, leukopenia. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Preparation Products And Raw materials
Raw materialsFormamide-->1,2-Diaminopropane-N,N,N',N'-tetraacetic acid
Dexrazoxane Pemetrexed Disodium 4-methylpiperazine-2,6-dione (S)-(-)-1,2-Diaminopropane dihydrochloride Dexrazoxane hydrochloride Piperazine-2,6-dione 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- ETHYLIMINUM 4-(2-AMINO-ETHYL)-PIPERAZIN-2-ONE 1-(2-DIETHYLAMINOETHYL)PIPERAZINE 4,4-(2,3-BUTANEDIYL)-BIS(2,6-PIPERAZINEDIONE) 1,1'-ethylenedipiperazine
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