Tinib Antineoplastic drugs

Tinib antineoplastic drug is a new class of biological targeted treatment of cancer. Nowadays, on the common market of our country, there are Gefitinib, Imatinib, Imatinib Mesylate, Nilotinib, Sunitinib and Lapatinib.

Gefitinib is a specific anti-tumor targeted therapy with high specificity which has been developed by AstraZeneca UK. It is the first kind of targeted drug for the treatment of non-small cell lung cancer (NSCLC). It would work by selectively inhibiting the signal transduction pathway of epidermal growth factor receptor tyrosine kinase (EGFR-TK).

Imatinib is a new 2-anilino pyrimidine tyrosine kinase inhibitor. And it can effectively inhibit Bcr-abl tyrosine kinase activity at the cellular level, which is the product of Ph chromosome abnormalities of Chronic Myelogenous Leukemia (CML). So Imatinib can selectively inhibit the Ber-abl positive cell lines proliferation and induce cell apoptosis the cells of patients who have been tortured by c Chronic Myelogenous Leukemia (CML).

Sunitinib is multi-targeted tyrosine kinase inhibitors, including platelet-derived growth factor receptor, vascular endothelial growth factor receptor activation and various forms of mutant stem cell factor receptor. It can inhibit the expression dysregulation of tumor cell RTKs and can inhibit the anti-tumor angiogenesis as well. Metabolization of Sunitinib relies on cytochrome P450 enzyme. Sunitinib is suitable for gastrointestinal stromal tumor of imatinib-resistant or treatment-progressors, or for the treatment of renal cell carcinoma.

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Structure Chemical Name CAS MF
Imatinib mesylate Imatinib mesylate 220127-57-1 C30H35N7O4S
Gefitinib Gefitinib 184475-35-2 C22H24ClFN4O3
Lapatinib Lapatinib 231277-92-2 C29H26ClFN4O4S
Erlotinib Erlotinib 183321-74-6 C22H23N3O4
Imatinib Imatinib 152459-95-5 C29H31N7O
Nilotinib Nilotinib 641571-10-0 C28H22F3N7O
Bosutinib Bosutinib 380843-75-4 C26H29Cl2N5O3
Axitinib Axitinib 319460-85-0 C22H18N4OS
Vandetanib Vandetanib 443913-73-3 C22H24BrFN4O2
17-AAG 17-AAG 75747-14-7 C31H43N3O8
Sunitinib Malate Sunitinib Malate 341031-54-7 C26H33FN4O7
Erlotinib hydrochloride Erlotinib hydrochloride 183319-69-9 C22H24ClN3O4
Neratinib Neratinib 698387-09-6 C30H29ClN6O3
Dasatinib Dasatinib 302962-49-8 C22H26ClN7O2S
Dasatinib monohydrate Dasatinib monohydrate 863127-77-9 C22H28ClN7O3S
Saracatinib Saracatinib 379231-04-6 C27H32ClN5O5
Canertinib Canertinib 267243-28-7 C24H25ClFN5O3
Canertinib dihydrochloride Canertinib dihydrochloride 289499-45-2 C24H27Cl3FN5O3
Piperazinone, 3-(2-thienyl)- (9CI) Piperazinone, 3-(2-thienyl)- (9CI) 86696-86-8 C8H10N2OS
N-Boc-N-Desmethyl Imatinib N-Boc-N-Desmethyl Imatinib 1076199-23-9 C33H37N7O3
N-DESMETHYL IMATINIB N-DESMETHYL IMATINIB 1356565-46-2 C42H47N9O2
IMatinib Meta-Methyl-piperazine IMatinib Meta-Methyl-piperazine
Volitinib Volitinib 1313725-88-0 C17H15N9
tenylidone tenylidone 893-01-6 C16H14OS2
Sorafenib Tosylate Sorafenib Tosylate C4H7NO4
Lapatinib Ditosylate Lapatinib Ditosylate 388082-77-7 C36H34ClFN4O7S2
Mubritinib Mubritinib 366017-09-6 C25H23F3N4O2
CANERTINIB CANERTINIB C27H32ClN5O5
Fruquintinib|HMPL-013 Fruquintinib|HMPL-013 1194506-26-7 C21H19N3O5
Tandutinib Tandutinib 387867-13-2 C31H42N6O4
Tenidap Tenidap 120210-48-2 C14H9ClN2O3S
Dovitinib Dovitinib 915769-50-5 C24H29FN6O5
4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZONITRILE 4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZONITRILE 125743-63-7 C13H17N3
IMatinib Para-diaMinoMethylbenzene IMatinib Para-diaMinoMethylbenzene 1026753-54-7 C29H31N7O
Lestaurtinib Lestaurtinib 111358-88-4 C26H21N3O4
TICRYNAFEN TICRYNAFEN C13H8Cl2O4S
Tilisolol Tilisolol 85136-71-6 C17H24N2O3
Phosphomycin Sodium Phosphomycin Sodium 103923-27-9 C21H38N2
N-Desmethyl Imatinib N-Desmethyl Imatinib 404844-02-6 C28H29N7O
DODECYL METHANETHIOSULFONATE DODECYL METHANETHIOSULFONATE C13H28O2S2
Telatinib Telatinib 332012-40-5 C20H16ClN5O3
Bafetinib Bafetinib 887650-05-7 C30H31F3N8O
Tenilapine Tenilapine 82650-83-7
Imatinib (Piperidine)-N-oxide Imatinib (Piperidine)-N-oxide 571186-91-9 C29H31N7O2
Afatinib Afatinib 850140-72-6 C24H25ClFN5O3
Imatinib (Pyridine)-N-oxide Imatinib (Pyridine)-N-oxide 571186-92-0 C29H31N7O2
Pelitinib Pelitinib 326894-84-2 C24H23ClFN5O2
Octenidine dihydrochloride Octenidine dihydrochloride 70775-75-6 C36H64Cl2N4
brotianide brotianide 23233-88-7 C15H10Br2ClNO2S
Antienite Antienite 5029-05-0 C9H8N2S2
Teniloxazine Teniloxazine 62473-79-4 C16H19NO2S
Bafetinib Bafetinib 859212-16-1 C30H31F3N8O
iMatinib related substance C iMatinib related substance C 938082-57-6 C29H31N7O2
Sunitinib Sunitinib 557795-19-4 C22H27FN4O2
4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 590424-04-7 C18H31N3O3
4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile 4,5-Bis(2-methoxyethoxy)-2-nitrobenzonitrile 236750-65-5 C13H16N2O6
4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline 183321-84-8 C20H19N3O4
iMatinib related substance B iMatinib related substance B 571186-93-1 C29H31N7O3
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