Alkylating antineoplastic

In all kinds of anti-tumor chemotherapies, Alkylating agent is the earliest and most widely used application of the anticancer drugs, and it is also one of the biggest families of anti-tumor chemotherapies. Since the application of nitrogen mustard treatment of malignant tumors from 1942, alkylating agents has become one of the most important type of chemotherapeutic drugs.

The main features of these drugs is a common molecular structure cytotoxic components that molecules containing alkyl group usually contains one or two alkyl groups, and therefore are called as single-function or bifunctional alkylating agent. These alkyl groups typically can be converted to the electron-deficient active intermediate products, which could covalent bind with the electron-donating group (eg an amino group, a mercapto group, a hydroxyl group, a carboxylic acid group, a phosphoric acid group, etc. ) contained in the biomacromolecules of cells (such as DNA, RNA and protein) and then there occurs alkylation reaction. This could cause the loss of these cellular components in cell metabolism, composition of mutated cells and cell division, resulting in cell death. Compared with other anticancer drugs, this type of drugs has little resistance, and there is little cross resistance reaction between alkylating agents and non-alkylating agents as well as between alkylating agents. Even if there is reaction, it’s a mild reaction. Bone marrow suppressions and gastrointestinal reactions are common untoward effects of this type of drugs. The most commonly used alkylating antineoplastic agents can be divided into these several types: mustard and its derivatives (diclofenac diethylamine class), ethylene imines, methane sulfonic acid esters, nitrosourea, epoxides and others.

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Structure Chemical Name CAS MF
Bendamustine hydrochloride Bendamustine hydrochloride 3543-75-7 C16H22Cl3N3O2
Mizolastine Mizolastine 108612-45-9 C24H25FN6O
Dacarbazine Dacarbazine 4342-03-4 C6H10N6O
Mechlorethamine hydrochloride Mechlorethamine hydrochloride 55-86-7 C5H12Cl3N
BEPOTASTINE BESILATE BEPOTASTINE BESILATE 190786-44-8 C27H31ClN2O6S
Busulfan Busulfan 55-98-1 C6H14O6S2
Nimustine hydrochloride Nimustine hydrochloride 55661-38-6 C9H14Cl2N6O2
Melphalan Melphalan 148-82-3 C13H18Cl2N2O2
Carmustine Carmustine 154-93-8 C5H9Cl2N3O2
Triethylenethiophosphoramide Triethylenethiophosphoramide 52-24-4 C6H12N3PS
Lomustine Lomustine 13010-47-4 C9H16ClN3O2
Chlorambucil Chlorambucil 305-03-3 C14H19Cl2NO2
NIMUSTINE HYDROCHLORIDE NIMUSTINE HYDROCHLORIDE 52208-23-8 C9H14Cl2N6O2
Bendamustine Bendamustine 97832-05-8 C16H21Cl2N3O2.HCl
Estramustine sodium phosphate Estramustine sodium phosphate 52205-73-9 C23H33Cl2NNaO6P
trans-2,3-Dibromo-2-butene-1,4-diol trans-2,3-Dibromo-2-butene-1,4-diol 3234-02-4 C4H6Br2O2
Estramustine Estramustine 2998-57-4 C23H31Cl2NO3
Altretamine Altretamine 645-05-6 C9H18N6
Ditiomustine Ditiomustine 82599-22-2 C10H18Cl2N6O4S2
Enpromate Enpromate 10087-89-5 C22H23NO2
Neptamustine Neptamustine 73105-03-0 C8H16ClN3O2
GLYFOSFIN GLYFOSFIN
NITROCAPHANE NITROCAPHANE C14H19Cl2N3O4
Ecomustine Ecomustine 98383-18-7 C10H18ClN3O6
Methoxymerphalan Methoxymerphalan
Semustine Semustine 13909-09-6 C10H18ClN3O2
epipropidine epipropidine 5696-17-3 C16H28N2O2
Tauromustine Tauromustine 85977-49-7 C7H15ClN4O4S
URACIL  MUSTARD URACIL MUSTARD 66-75-1 C8H11Cl2N3O2
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL 488-41-5 C6H12Br2O4
Tallimustine Tallimustine 115308-98-0 C32H38Cl2N10O4
Nimustine Nimustine 42471-28-3 C9H13ClN6O2
BendaMustine IMpurity B BendaMustine IMpurity B
Ranimustine Ranimustine 58994-96-0 C10H18ClN3O7
carboquone carboquone 24279-91-2 C15H19N3O5
Betahistine Hydrochloride Betahistine Hydrochloride 15430-48-5 C8H13ClN2
Bofumustine Bofumustine 55102-44-8 C18H21ClN4O9
BendaMustine IMpurity A   BendaMustine IMpurity A   109882-26-0 Br-
Galamustine Galamustine 105618-02-8 C10H19Cl2NO5
elmustine elmustine 60784-46-5 C5H10ClN3O3
Ambamustine Ambamustine 85754-59-2 C29H39Cl2FN4O4S
Spiromustine Spiromustine 56605-16-4 C14H23Cl2N3O2
TRIETHYLENEMELAMINE TRIETHYLENEMELAMINE 51-18-3 C9H12N6
trisethyleneiminoquinone trisethyleneiminoquinone 68-76-8 C12H13N3O2
BendaMustine IMpurity C   BendaMustine IMpurity C   1313020-25-5 C19H27Cl2N3O2
prednimustine prednimustine 29069-24-7 C35H45Cl2NO6
Formylmerphalan Formylmerphalan
Predmustine Predmustine
BETAMERPHALAN BETAMERPHALAN
Fotemustine Fotemustine 92118-27-9 C9H19ClN3O5P
2,6-DIHYDROXY-4-METHYL-5-[BIS(2-CHLOROETHYL)AMINO]PYRIMIDINE 2,6-DIHYDROXY-4-METHYL-5-[BIS(2-CHLOROETHYL)AMINO]PYRIMIDINE 520-09-2 C9H13Cl2N3O2
Chlormethine Chlormethine 51-75-2 C5H11Cl2N
estra-1,3,5(10)-triene-3,17beta-diol 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) estra-1,3,5(10)-triene-3,17beta-diol 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) 4891-15-0 C23H32Cl2NO6P
Estramustine Na PH Estramustine Na PH
Dianhydrodulcitol Dianhydrodulcitol
Solaziquone Solaziquone
OCAPHANE OCAPHANE
Mechlorethaminoxide Mechlorethaminoxide
mannomustine mannomustine 576-68-1 C10H22Cl2N2O4
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