Anti-tuberculous mycobacterium leprae drugs

In addition to Mycobacterium tuberculosis, other mycobacteria can also be pathogenic to humans. Because of their colonies formed during culture are not typical features of Mycobacterium tuberculosis, they are given the name "atypical mycobacteria", while now they are more commonly referred to as "non-tuberculous mycobacteria" (NTM).Mycobacterium tuberculosis can be divided into 4 groups according to the pigment production or rapid growth (Runyon, 1965). After the initial report published of Runyon's classification system, the report of disease caused by NTM lesions in the southeastern United States emerged. The epidemiology of these patients and general TB patients are different. These patients are older, most of whom are white, and their lungs are often suffered from chronic disease. However, the existing anti-TB drug treatment are ineffective. In order to understand the occurrence of NTM disease, we have found some information in the United States’ 1981-1983 epidemiological studies: the highest incidence is Mycobacterium avium complex (MAC), followed by Mycobacterium kansas and mycobacterium - Mycobacterium tumefaciens (O Brien et al., 1987). In some areas of the United States, NTM may be as common as tuberculosis. Human infections appear to arise from mycobacteria in the environment.
Leprosy is caused by leprosy bacillus infection. Mycobacterium leprae and Mycobacterium tuberculosis both belong to the genus Mycobacterium, and they have similar points in the form and response to drugs. Some anti-tuberculosis drugs can also be used for the treatment of leprosy, such as rifampicin which is the main leprosy drug, ammonia thiourea which also have a role. Anti-leprosy drugs are mainly sulfone drugs.
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Structure Chemical Name CAS MF
4,4'-Diaminodiphenylsulfone 4,4'-Diaminodiphenylsulfone 80-08-0 C12H12N2O2S
TMC-207 TMC-207 843663-66-1 C32H31BrN2O2
Isoniazid Isoniazid 54-85-3 C6H7N3O
Pyrazinamide Pyrazinamide 98-96-4 C5H5N3O
2-Mercaptobenzimidazole 2-Mercaptobenzimidazole 583-39-1 C7H6N2S
4-Aminosalicylic acid 4-Aminosalicylic acid 65-49-6 C7H7NO3
Ethionamide Ethionamide 536-33-4 C8H10N2S
Protionamide Protionamide 14222-60-7 C9H12N2S
Thalidomide Thalidomide 50-35-1 C13H10N2O4
Calcium 4-aminosalicylate Calcium 4-aminosalicylate 133-15-3 C7H9CaNO3
Sodium 4-aminosalicylate dihydrate Sodium 4-aminosalicylate dihydrate 6018-19-5 C7H10NNaO4
LYSIONOTIN LYSIONOTIN 152743-19-6 C18H16O7
Sodium 4-aminosalicylate Sodium 4-aminosalicylate 133-10-8 C7H6NNaO3
Clofazimine Clofazimine 2030-63-9 C27H22Cl2N4
Ethambutol dihydrochloride Ethambutol dihydrochloride 1070-11-7 C10H24N2O2.2ClH
THIACETAZONE THIACETAZONE 104-06-3 C10H12N4OS
thiambutosine thiambutosine 500-89-0 C19H25N3OS
Aldesulfone Sodium Aldesulfone Sodium 144-75-2 C14H14N2Na2O6S3
Etocarlide Etocarlide 1234-30-6 C17H20N2O2S
Ftivazide Ftivazide 149-17-7 C14H13N3O3
Pasiniazid Pasiniazid 2066-89-9 C13H14N4O4
isonoazone isonoazone
Ethambutol Ethambutol 74-55-5 C10H24N2O2
methaniazide methaniazide 13447-95-5 C7H9N3O4S
Isoniazid-D4 Isoniazid-D4 774596-24-6 C6H7N3O
1-PHENYL-1-PROPYNE 1-PHENYL-1-PROPYNE 623-32-5 C20H36O2
Furilazone Furilazone
solasulfone solasulfone 133-65-3 C30H28N2O14S5.4Na
acediasulfone sodium acediasulfone sodium 127-60-6 C14H15N2NaO4S
ISONICOTINIC ACID 2,2'-METHYLENEDIHYDRAZIDE� ISONICOTINIC ACID 2,2'-METHYLENEDIHYDRAZIDE 1707-15-9 C13H14N6O2
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