Sulfonamides and synergist

Sulfa drugs developed rapidly in the 1930s, and there had been more than 20 species of the drugs for the clinical application. the status of sulfa drugs in chemotherapeutic agents declined after 1940s due to the occurrence of penicillin and other antibiotics. But sulfa drugs, whose  antibacterial activity will be enhanced when combined with trimethoprim the antibacterial synergist, are still commonly used antibacterial drugs for the advantages of broad antibacterial spectrum, enabled to be administered orally, more rapid absorption. Clarifying the mechanism of the action of sulfa drugs established anti-metabolic theory and opened up a new way for the development of new drugs. Currently there are sulfadiazine and sulfamethoxazole that are used most widely in clinical.

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Structure Chemical Name CAS MF
4-(5-BROMO-2-METHOXYBENZENESULPHONYL)MORPHOLINE 4-(5-BROMO-2-METHOXYBENZENESULPHONYL)MORPHOLINE 325809-68-5 C11H14BrNO4S
5-(N,N-DIMETHYLSULFAMOYL)-2-METHYLPHENYLBORONIC ACID 5-(N,N-DIMETHYLSULFAMOYL)-2-METHYLPHENYLBORONIC ACID 871332-99-9 C9H14BNO4S
4-BROMO-N-TERT-BUTYL-BENZENESULFONAMIDE 4-BROMO-N-TERT-BUTYL-BENZENESULFONAMIDE 93281-65-3 C10H14BrNO2S
4-Bromo-N-isopropylbenzenesulfonamide 4-Bromo-N-isopropylbenzenesulfonamide 1984-27-6 C9H12BrNO2S
2-METHYL-5-(PIPERIDIN-1-YLSULFONYL)PHENYLBORONIC ACID 2-METHYL-5-(PIPERIDIN-1-YLSULFONYL)PHENYLBORONIC ACID 871333-00-5 C12H18BNO4S
1-(5-BROMO-2-METHOXYBENZENESULPHONYL)PIPERIDINE 1-(5-BROMO-2-METHOXYBENZENESULPHONYL)PIPERIDINE 295360-83-7 C12H16BrNO3S
2-Bromo-N,N-diethylbenzenesulphonamide 2-Bromo-N,N-diethylbenzenesulphonamide 65000-12-6 C10H14BrNO2S
4-[(2-Bromophenyl)sulphonyl]morpholine 4-[(2-Bromophenyl)sulphonyl]morpholine 688798-57-4 C10H12BrNO3S
4-Methoxyphenyl mesylate, 4-[(Methylsulphonyl)oxy]anisole 4-Methoxyphenyl mesylate, 4-[(Methylsulphonyl)oxy]anisole 19013-30-0 C8H10O4S
5-BROMO-N,N-DIMETHYL-2-METHOXYBENZENESULFONAMIDE 5-BROMO-N,N-DIMETHYL-2-METHOXYBENZENESULFONAMIDE 871269-16-8 C9H12BrNO3S
3-(TERT-BUTYLAMINOSULPHONYL)BENZENEBORONIC ACID 3-(TERT-BUTYLAMINOSULPHONYL)BENZENEBORONIC ACID 221290-14-8 C10H16BNO4S
3-(3-BROMOPHENYLSULPHONAMIDO)BENZENEBORONIC ACID 95 3-(3-BROMOPHENYLSULPHONAMIDO)BENZENEBORONIC ACID 95 913835-31-1 C12H11BBrNO4S
3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID 3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID 90610-69-8 C9H11NO4S
4-(N-CYCLOHEXYLSULPHONAMIDO)BENZENEBORONIC ACID 4-(N-CYCLOHEXYLSULPHONAMIDO)BENZENEBORONIC ACID 871329-66-7 C12H18BNO4S
4-(1-PIPERIDINYLSULFONYL)PHENYLBORONIC ACID 4-(1-PIPERIDINYLSULFONYL)PHENYLBORONIC ACID 486422-58-6 C11H16BNO4S
4-(N-THIOMORPHOLINYLSULFONYL)PHENYLBORONIC ACID 4-(N-THIOMORPHOLINYLSULFONYL)PHENYLBORONIC ACID 871329-69-0 C10H14BNO4S2
3-Bromo-N-propylbenzamide 3-Bromo-N-propylbenzamide 35306-74-2 C10H12BrNO
N-BUTYL 3-NITROBENZENESULFONAMIDE N-BUTYL 3-NITROBENZENESULFONAMIDE 89840-72-2 C10H14N2O4S
4-(4-MORPHOLINYLSULFONYL)PHENYLBORONIC ACID 4-(4-MORPHOLINYLSULFONYL)PHENYLBORONIC ACID 486422-69-9 C14H24BN3O4S
3-(N,N-DIETHYLSULPHONAMIDO)BENZENEBORONIC ACID 3-(N,N-DIETHYLSULPHONAMIDO)BENZENEBORONIC ACID 871329-58-7 C10H16BNO4S
Sulfisoxazole Sulfisoxazole 127-69-5 C11H13N3O3S
Sulfaquinoxaline Sulfaquinoxaline 59-40-5 C14H12N4O2S
5-BROMO-2-METHOXY-N-METHYLBENZENESULFONAMIDE 5-BROMO-2-METHOXY-N-METHYLBENZENESULFONAMIDE 871269-17-9 C8H10BrNO3S
N-METHYL 3-NITROBENZENESULFONAMIDE N-METHYL 3-NITROBENZENESULFONAMIDE 58955-78-5 C7H8N2O4S
1-(3-BROMOPHENYLSULFONYL)PIPERIDINE 1-(3-BROMOPHENYLSULFONYL)PIPERIDINE 871269-12-4 C11H14BrNO2S
4-(Pyridin-3-ylsulphonyl)morpholine 4-(Pyridin-3-ylsulphonyl)morpholine 26103-48-0 C9H12N2O3S
2-Bromo-N-methylbenzenesulphonamide 2-Bromo-N-methylbenzenesulphonamide 98192-14-4 C7H8BrNO2S
1-Fluoro-4-(pyrrolidinosulfonyl)benzene 1-Fluoro-4-(pyrrolidinosulfonyl)benzene 157187-14-9 C10H12FNO2S
N-Benzyl-2-bromobenzenesulfonamide N-Benzyl-2-bromobenzenesulfonamide 321704-27-2 C13H12BrNO2S
4-BROMO-N-BUTYLBENZENESULPHONAMIDE 4-BROMO-N-BUTYLBENZENESULPHONAMIDE 1984-28-7 C10H14BrNO2S
4-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE 4-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE 59724-43-5 C8H10BrNO3S
5-BROMO-N-ETHYL-2-METHOXYBENZENESULPHONAMIDE 5-BROMO-N-ETHYL-2-METHOXYBENZENESULPHONAMIDE 717892-29-0 C9H12BrNO3S
5-BROMOPYRIDINE-3-SULPHONAMIDE 98 5-BROMOPYRIDINE-3-SULPHONAMIDE 98 62009-33-0 C5H5BrN2O2S
4-(4-BROMOBENZENESULFONYL)MORPHOLINE 4-(4-BROMOBENZENESULFONYL)MORPHOLINE 834-67-3 C10H12BrNO3S
Sulfalen Sulfalen 152-47-6 C11H12N4O3S
Sulfameter Sulfameter 651-06-9 C11H12N4O3S
N-BENZYL 4-BROMOBENZENESULFONAMIDE N-BENZYL 4-BROMOBENZENESULFONAMIDE 3609-87-8 C13H12BrNO2S
4-(N-(3-CHLOROPROPYL)SULFAMOYL)PHENYLBORONIC ACID 4-(N-(3-CHLOROPROPYL)SULFAMOYL)PHENYLBORONIC ACID 874219-48-4 C9H13BClNO4S
4-METHOXY-3-(PYRROLIDIN-1-YLSULPHONYL)BENZENEBORONIC ACID 4-METHOXY-3-(PYRROLIDIN-1-YLSULPHONYL)BENZENEBORONIC ACID 874219-52-0 C11H16BNO5S
4-METHOXY-3-(N,N-DIETHYLSULFAMOYL)PHENYLBORONIC ACID 4-METHOXY-3-(N,N-DIETHYLSULFAMOYL)PHENYLBORONIC ACID 871333-03-8 C11H18BNO5S
2-METHYL-5-(PYRROLIDIN-1-YLSULFONYL)PHENYLBORONIC ACID 2-METHYL-5-(PYRROLIDIN-1-YLSULFONYL)PHENYLBORONIC ACID 871333-01-6 C11H16BNO4S
5-(N-TERT-BUTYLSULFAMOYL)-2-METHYLPHENYLBORONIC ACID 5-(N-TERT-BUTYLSULFAMOYL)-2-METHYLPHENYLBORONIC ACID 874219-47-3 C11H18BNO4S
3-BROMO,N, N-DIMETHYLBENZENESULFONAMIDE 3-BROMO,N, N-DIMETHYLBENZENESULFONAMIDE 153435-80-4 C8H10BrNO2S
3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE 118837-66-4 C9H14N2O2S
3-(Pyrrolidin-1-ylsulphonyl)pyridine 3-(Pyrrolidin-1-ylsulphonyl)pyridine 26103-51-5 C9H12N2O2S
1-(2-Boronophenylsulfonyl)piperidine 1-(2-Boronophenylsulfonyl)piperidine 957034-87-6 C11H16BNO4S
4-BROMO-N,N-DIETHYLBENZENESULPHONAMIDE 4-BROMO-N,N-DIETHYLBENZENESULPHONAMIDE 90944-62-0 C10H14BrNO2S
3-(N-BENZYLSULFAMOYL)-4-METHOXYPHENYLBORONIC ACID 3-(N-BENZYLSULFAMOYL)-4-METHOXYPHENYLBORONIC ACID 874219-51-9 C13H14BNO5S
4-(N-BENZYLSULPHONAMIDO)BENZENEBORONIC ACID 4-(N-BENZYLSULPHONAMIDO)BENZENEBORONIC ACID 548769-96-6 C13H14BNO4S
4-(1-PYRROLIDINYLSULFONYL)PHENYLBORONIC ACID 4-(1-PYRROLIDINYLSULFONYL)PHENYLBORONIC ACID 486422-57-5 C10H14BNO4S
4-BROMO-N-CYCLOHEXYLBENZENESULPHONAMIDE 4-BROMO-N-CYCLOHEXYLBENZENESULPHONAMIDE 7454-76-4 C12H16BrNO2S
4-BROMO-2-(AMINOSULPHONYL)ANISOLE 4-BROMO-2-(AMINOSULPHONYL)ANISOLE 23095-14-9 C7H8BrNO3S
3-AMINO-N-BUTYLBENZENESULFONAMIDE 3-AMINO-N-BUTYLBENZENESULFONAMIDE 143173-93-7 C10H16N2O2S
3-METHYLSULFAMOYLPHENYLBORONIC ACID 3-METHYLSULFAMOYLPHENYLBORONIC ACID 871329-75-8 C7H10BNO4S
2-Bromo-N-(fur-2-ylmethyl)benzenesulphonamide 2-Bromo-N-(fur-2-ylmethyl)benzenesulphonamide 849056-66-2 C11H10BrNO3S
3-Bromo-N-isopropyl-5-nitrobenzamide 3-Bromo-N-isopropyl-5-nitrobenzamide 941294-16-2 C10H11BrN2O3
5-(N,N-DIETHYLSULFAMOYL)-2-METHYLPHENYLBORONIC ACID 5-(N,N-DIETHYLSULFAMOYL)-2-METHYLPHENYLBORONIC ACID 871329-80-5 C11H18BNO4S
1-(4-BORONOPHENYLSULFONYL)AZETIDINE 1-(4-BORONOPHENYLSULFONYL)AZETIDINE 871329-68-9 C9H12BNO4S
3-N-BUTYLSULFAMOYLPHENYLBORONIC ACID 3-N-BUTYLSULFAMOYLPHENYLBORONIC ACID 871329-78-1 C10H16BNO4S
N-Phenethyl 2-bromobenzenesulphonamide N-Phenethyl 2-bromobenzenesulphonamide 849141-69-1 C14H14BrNO2S
1-(4-Bromophenylsulfonyl)piperidin-4-one 1-(4-Bromophenylsulfonyl)piperidin-4-one 929000-54-4 C11H12BrNO3S
5-(N-BENZYLSULFAMOYL)-2-METHYLPHENYLBORONIC ACID 5-(N-BENZYLSULFAMOYL)-2-METHYLPHENYLBORONIC ACID 871329-73-6 C14H16BNO4S
4-METHOXY-3-(MORPHOLIN-4-YLSULPHONYL)BENZENEBORONIC ACID 4-METHOXY-3-(MORPHOLIN-4-YLSULPHONYL)BENZENEBORONIC ACID 871333-02-7 C11H16BNO6S
N-CYCLOPROPYL 3-NITROBENZENESULFONAMIDE N-CYCLOPROPYL 3-NITROBENZENESULFONAMIDE 401589-92-2 C9H10N2O4S
3-BROMO-N,N-DIETHYLBENZENESULPHONAMIDE 3-BROMO-N,N-DIETHYLBENZENESULPHONAMIDE 871269-11-3 C10H14BrNO2S
1-(3-BROMO-4-METHYLPHENYLSULFONYL)MORPHOLINE 1-(3-BROMO-4-METHYLPHENYLSULFONYL)MORPHOLINE 850429-74-2 C11H14BrNO3S
4-(N-ETHYLSULPHONAMIDO)BENZENEBORONIC ACID 4-(N-ETHYLSULPHONAMIDO)BENZENEBORONIC ACID 871329-65-6 C8H12BNO4S
5-BROMO-N-BUTYL-2-METHOXYBENZENESULFONAMIDE 5-BROMO-N-BUTYL-2-METHOXYBENZENESULFONAMIDE 871269-18-0 C11H16BrNO3S
1-(3-NITROPHENYLSULFONYL)PIPERIDINE 1-(3-NITROPHENYLSULFONYL)PIPERIDINE 91619-31-7 C11H14N2O4S
3-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE 97 3-BROMO-N-(2-HYDROXYETHYL)BENZENESULPHONAMIDE 97 911111-96-1 C8H10BrNO3S
3-(2-(Pyrrolidin-1-yl)ethylcarbamoyl)phenylboronic acid, HCl 3-(2-(Pyrrolidin-1-yl)ethylcarbamoyl)phenylboronic acid, HCl 957061-03-9 C13H20BClN2O3
3-Ethylsulfamoylpyridine 3-Ethylsulfamoylpyridine 4810-40-6 C7H10N2O2S
4-(3-NITROPHENYLSULFONYL)MORPHOLINE 4-(3-NITROPHENYLSULFONYL)MORPHOLINE 91619-33-9 C10H12N2O5S
3-BROMO-N-ISOPROPYLBENZENESULPHONAMIDE 3-BROMO-N-ISOPROPYLBENZENESULPHONAMIDE 871269-08-8 C9H12BrNO2S
3-(N-BENZYLSULFAMOYL)PHENYLBORONIC ACID 3-(N-BENZYLSULFAMOYL)PHENYLBORONIC ACID 690662-91-0 C13H14BNO4S
5-BROMO-N-(2-HYDROXYETHYL)-2-METHOXYBENZENESULFONAMIDE 5-BROMO-N-(2-HYDROXYETHYL)-2-METHOXYBENZENESULFONAMIDE 871269-14-6 C9H12BrNO4S
1,1,3-TRIOXO-TETRAHYDRO-2H-1,2-THIAZINE 1,1,3-TRIOXO-TETRAHYDRO-2H-1,2-THIAZINE 913836-20-1 C4H7NO3S
3-Bromo-4-methylbenzenesulphonamide 3-Bromo-4-methylbenzenesulphonamide 210824-69-4 C7H8BrNO2S
3-AMINO-N-CYCLOHEXYLBENZENESULFONAMIDE 3-AMINO-N-CYCLOHEXYLBENZENESULFONAMIDE 61886-26-8 C12H18N2O2S
3-(PIPERIDIN-1-YLSULFONYL)PHENYLBORONIC ACID 3-(PIPERIDIN-1-YLSULFONYL)PHENYLBORONIC ACID 690662-96-5 C11H16BNO4S
2-Bromo-N,N-dipropylbenzenesulphonamide 2-Bromo-N,N-dipropylbenzenesulphonamide 65000-11-5 C12H18BrNO2S
Phenyl 4-bromobenzenesulphonate 98% Phenyl 4-bromobenzenesulphonate 98% 5455-14-1 C12H9BrO3S
1-(4-BROMOPHENYLSULFONYL)AZETIDINE 1-(4-BROMOPHENYLSULFONYL)AZETIDINE 530081-57-3 C9H10BrNO2S
4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE 4-BROMO-N-[2-(TBDMSO)ETHYL]BENZENESULFONAMIDE 850429-52-6 C14H24BrNO3SSi
N-ISOPROPYL 3-NITROBENZENESULFONAMIDE N-ISOPROPYL 3-NITROBENZENESULFONAMIDE 28860-10-8 C9H12N2O4S
N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide 941294-29-7 C14H14BrNO2S
3-BROMO-N-BUTYLBENZENESULPHONAMIDE 3-BROMO-N-BUTYLBENZENESULPHONAMIDE 871269-09-9 C10H14BrNO2S
4-(2-HYDROXYETHYLSULFAMOYL)PHENYLBORONIC ACID 4-(2-HYDROXYETHYLSULFAMOYL)PHENYLBORONIC ACID 850568-77-3 C8H12BNO5S
5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULPHONAMIDE 97 5-BROMO-N-CYCLOPROPYL-2-METHOXYBENZENESULPHONAMIDE 97 914302-35-5 C10H12BrNO3S
5-BROMO-N,N-DIETHYL-2-METHOXYBENZENESULFONAMIDE 5-BROMO-N,N-DIETHYL-2-METHOXYBENZENESULFONAMIDE 428471-30-1 C11H16BrNO3S
N-ETHYL 3-NITROBENZENESULFONAMIDE N-ETHYL 3-NITROBENZENESULFONAMIDE 28860-09-5 C8H10N2O4S
1-(3-BROMO-4-METHYLPHENYLSULFONYL)PIPERIDINE 1-(3-BROMO-4-METHYLPHENYLSULFONYL)PIPERIDINE 850429-73-1 C12H16BrNO2S
N,N-DIMETHYL 3-NITROBENZENESULFONAMIDE N,N-DIMETHYL 3-NITROBENZENESULFONAMIDE 26199-83-7 C8H10N2O4S
3-AMINO-N-BENZYLBENZENESULFONAMIDE 3-AMINO-N-BENZYLBENZENESULFONAMIDE 303780-52-1 C13H14N2O2S
3-AMINO-N-ETHYLBENZENESULFONAMIDE 3-AMINO-N-ETHYLBENZENESULFONAMIDE 56445-08-0 C8H12N2O2S
3-(N-ISOPROPYLSULFAMOYL)PHENYLBORONIC ACID 3-(N-ISOPROPYLSULFAMOYL)PHENYLBORONIC ACID 871329-77-0 C9H14BNO4S
N,N-Dimethyl 4-formyl-1H-imidazole-1-sulfonamide N,N-Dimethyl 4-formyl-1H-imidazole-1-sulfonamide 140174-48-7 C6H9N3O3S
1-(5-BROMO-2-METHOXYBENZENESULPHONYL)PYRROLIDINE 1-(5-BROMO-2-METHOXYBENZENESULPHONYL)PYRROLIDINE 691381-10-9 C11H14BrNO3S
N-BENZYL 3-BROMOBENZENESULFONAMIDE N-BENZYL 3-BROMOBENZENESULFONAMIDE 625470-36-2 C13H12BrNO2S
4-Bromo-N,N,3-trimethylbenzenesulphonamide 4-Bromo-N,N,3-trimethylbenzenesulphonamide 849532-31-6 C9H12BrNO2S
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