Diabetes insipidus Drugs

Diabetes insipidus is a kind of disease which results in the reduction of antidiuretic hormone secretion and release. The main symptoms of diabetes insipidus are polyuria, polydipsia and dehydration. And Drug therapy of diabetes insipidus refers to the drugs which could help improve those symptoms.
These drugs could be divided into two categories:
one is posterior pituitary preparation which contains antidiuretic hormone (or vasopressin), such as posterior lobe inhaler and injections, as well as the recent manmade vasopressin like Lysine vasopressin. They all belong to replacement therapy drugs, which could easily destroyed by trypsin. So these drugs cannot be administered orally but mucosal or parenteral administrations are suitable.

Another type of drugs for oral administration, such as hydrochlorothiazide, etc., is only efficient for the patients who have a mild diabetes insipidus. However, it has seldom effect on the patients who has suffered from a serious diabetes insipidus. For the function and usage, see the introduction of Diuretics.

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Structure Chemical Name CAS MF
Propiverine hydrochloride Propiverine hydrochloride 54556-98-8 C23H30ClNO3
Terlipressin acetate Terlipressin acetate 14636-12-5 C52H74N16O15S2
Oxybutynin hydrochloride Oxybutynin hydrochloride 1508-65-2 C22H32ClNO3
Argipressine Argipressine 113-79-1 C46H65N15O12S2
Oxybutynin Oxybutynin 5633-20-5 C22H31NO3
Desmopressin acetate Desmopressin acetate 16789-98-3 C48H68N14O14S2
Desmopressin Desmopressin 16679-58-6 C46H64N14O12S2
Vasopressin Vasopressin 9034-50-8 C43H67N15O12S2
DESMOPRESSIN DESMOPRESSIN 62288-83-9 C48H68N14O14S2
DESMOPRESSIN ACETATE DESMOPRESSIN ACETATE 62357-86-2 C48H68N14O14S2
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