Flunarizine

Flunarizine Basic information
Product Name:Flunarizine
Synonyms:(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine;(e)-piperazin;1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine;Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)-;Sibelium;Fluarizine;1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenyl-2-propenyl]piperazine;FLUNARIZINE
CAS:52468-60-7
MF:C26H26F2N2
MW:404.49
EINECS:257-937-5
Product Categories:
Mol File:52468-60-7.mol
Flunarizine Structure
Flunarizine Chemical Properties
Boiling point 511.3±50.0 °C(Predicted)
density 1.170±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka6.99±0.10(Predicted)
CAS DataBase Reference52468-60-7(CAS DataBase Reference)
NIST Chemistry ReferencePiperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (e)-(52468-60-7)
Safety Information
MSDS Information
Flunarizine Usage And Synthesis
OriginatorSibelium,Janssen,W. Germany,1977
UsesVasodilator.
DefinitionChEBI: Flunarizine is a diarylmethane.
Manufacturing ProcessA mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1- cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 21 hours. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This solution is boiled with activated charcoal, filtered and to the clear filtrate is added an excess of 2-propanol, previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and recrystallized from a mixture of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl) piperazine dihydrochloride, MP 251.5°C.
Therapeutic FunctionVasodilator
World Health Organization (WHO)Flunarizine, an antihistaminic and vasodilator agent, was introduced into medicine in 1970. It is indicated for the treatment of central and peripheral vascular disorders. However, its effectiveness in these conditions has not been convincingly demonstrated, and its use has been associated with adverse reactions involving the central nervous system, including extrapyramidal disturbances and depression. This has led several regulatory authorities to restrict the approved indications for products containing flunarizine.
FLUNARIZINE DIHYDROCHLORIDE REFERENCE SPECTRUM EPY(CRM STANDARD) Methyl FLUNARIZINE DIHYDROCHLORIDE FOR SYSTEM SUITABILITY EPY(CRM STANDARD) (R)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE FLUNARIZINE DIHYDROCHLORIDE - REFERENCE SPECTRUM Aligeron PHENYL VALERATE Stugeron TRANS-1-CINNAMYLPIPERAZINE 1-AdaMantanethylaMine Thiophanate-methyl 1-Phenyl-2-nitropropene (S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE FLUNARIZINE DIHYDROCHLORIDE MM(CRM STANDARD) FLUNARIZINE DIHYDROCHLORIDE FOR SYSTEM SUITABILITY FLUNARIZINE DIHYDROCHLORIDE IMP. A (EP) : 1-[BIS(4-FLUOROPHENYL)METHYL]-PIPERAZINE 2-METHYL-2-PROPENE-1-SULFONIC ACID SODIUM SALT FLUNARIZINE N-OXIDE DIHYDROCHLORIDE

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