ChemicalBook Product Catalog API Circulatory system drugs Peripheral vasodilators Tolperisone

Tolperisone

Tolperisone Basic information
Product Name:Tolperisone
Synonyms:AKOS 91983;1-piperidino-2-methyl-3-(p-tolyl)-3-propanone;2,4’-dimethyl-3-piperidino-propiophenon;2-methyl-3-piperidino-1-p-tolylpropan-1-one;mydeton;TOLPERISONE;α,4'-Dimethyl-β-piperidinopropiophenone;2-methyl-1-(4-methylphenyl)-3-piperidin-1-yl-propan-1-one
CAS:728-88-1
MF:C16H23NO
MW:245.36
EINECS:211-976-4
Product Categories:
Mol File:728-88-1.mol
Tolperisone Structure
Tolperisone Chemical Properties
Melting point 176.5°C
Boiling point 388.33°C (rough estimate)
density 0.9672 (rough estimate)
refractive index 1.5500 (estimate)
pka8.47±0.10(Predicted)
CAS DataBase Reference728-88-1(CAS DataBase Reference)
Safety Information
MSDS Information
Tolperisone Usage And Synthesis
OriginatorTolperisone hydrochloride,Shanghai Abochem Chemical Co.
DefinitionChEBI: 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone is an aromatic ketone.
Manufacturing ProcessTo 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.
Brand nameTolperisone Hydrochloride is JAN.
Therapeutic FunctionMuscle relaxant, Vasodilator
Synthesis Reference(s)Chemical and Pharmaceutical Bulletin, 42, p. 1676, 1994 DOI: 10.1248/cpb.42.1676
Tolperisone Preparation Products And Raw materials
Raw materialsParaformaldehyde
Methyl p-Toluenesulfonic acid Cefoperazone sodium +sulbactam sodium(1:1/2:1) Citric acid monohydrate Phenylacetone ETHANE Cefoperazone Calcium pyruvate Tribenuron methyl Cefoperazone sodium TOLPERISONE HCL,TOLPERISONE HYDROCHLORIDE Dimethyl sebacate Methanol Methyl salicylate Methyl acrylate Propiophenone Dimethyl ether Dimethyl carbonate
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