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| | Bunazosin hydrochloride Basic information |
| Product Name: | Bunazosin hydrochloride | | Synonyms: | 1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one hydrochloride;BUNAZOSIN HYDROCHLORIDE;Bunzaosin Hcl;Bunazosin Hcl;Detantol;E-643;Bunazosin, DETANTO;1-(4-Amino-6，7-dimethoxyquinazolin-2-y1)-4-butyrylhexahydro-lH-1，4-diazepine hydrochloride | | CAS: | 52712-76-2 | | MF: | C19H28ClN5O3 | | MW: | 409.91 | | EINECS: | | | Product Categories: | | | Mol File: | 52712-76-2.mol |  |
| | Bunazosin hydrochloride Chemical Properties |
| Melting point | 280-282° | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| Toxicity | LD50 oral in rat: 980mg/kg |
| | Bunazosin hydrochloride Usage And Synthesis |
| Description | Bunazosin hydrochloride is a selective αl-adrenergic antagonist related to
prazosin and useful in the treatment of hypertension. | | Originator | Eisai (Japan) | | Uses | Bunazosin Hydrochloride is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug. | | Definition | ChEBI: Bunazosin hydrochloride is a member of quinazolines. | | Manufacturing Process | 17.0 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 18.2 g of Nformylhomopiperazine
are added to 170 ml of butanol and the whole is
refluxed with stirring for 3 h. After completion of the reaction, the mixture is
cooled, and the crystals thus precipitated are filtered out, washed with a small
quantity of ethanol and air-dried. 25.0 g of crude 2-homopiperazino-4-amino-
6,7-dimethoxyquinazoline are obtained.
A solution of 2-homopiperazino-4-amino-6,7-dimethoxyquinazoline in 60 ml of
acetone is added dropwise to a solution of 2-butylcarboxylic acid chloride in
acetone under stirring and ice-cooling. After completion of the addition, the
stirring is continued for additional 1 h to complete the reaction. The crystals
thus precipitated are filtered out and the 1-(4-amino-6,7-dimethoxy-2-
quinazolinyl)hexahydro-4-(1-oxobutyl)-1H-1,4-diazepine, melting point 280-
282°C (recrystallized from a mixture of methanol-ethanol) is obtained. | | Brand name | DETANTOL | | Therapeutic Function | Antihypertensive |
| | Bunazosin hydrochloride Preparation Products And Raw materials |
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