Aldesulfone Sodium

Aldesulfone Sodium Basic information

Product Name:	Aldesulfone Sodium
Synonyms:	Novotrone;Sulfonylbis(p-phenyleneimino)bis(methanesulfinic acid)disodium salt;NSC 27222;SodiuM aldesulphone;SodiuM sulfoxone;Adesulfone Sodium;Aldesulfone Sodium;DISODIUM DIFORMALDEHYDESULFOXYLATE
CAS:	144-75-2
MF:	C14H14N2Na2O6S3
MW:	0
EINECS:
Product Categories:
Mol File:	144-75-2.mol

Aldesulfone Sodium Chemical Properties

Melting point	263-265 °C (decomp)
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White
Stability:	Stable. Incompatible with strong oxidizing agents.

Safety Information

Toxicity

LD50 oral in mouse: 10gm/kg

MSDS Information

Aldesulfone Sodium Usage And Synthesis

Originator	Diasone Sodium,Abbott,US,1947
Uses	Sodium Sulfoxone is used in tuberculosis therapy along with Streptomycin (S687500).
Manufacturing Process	About 20 grams of diamino diphenyl sulfone is dissolved in about 500 cc of ethyl alcohol (3A made up of 5 parts methyl alcohol and 100 parts of ethyl alcohol) by placing the ingredients in a flask provided with a reflux condenser and warming over a water bath. About 24 grams of pure grade, very finely powdered (40 to 60 mesh) sodium formaldehyde sulfoxylate is then rapidly added to the alcohol solution of diamino diphenyl sulfone and the mixture refluxed in the usual manner. It was found that the mixture should be refluxed for a total of 5 hours and that a precipitate starts to form near the 3 hour period. The reaction mixture is then cooled to 15°C and kept at this temperature for about 1 hour. The precipitate formed in the filtrate is filtered off rapidly and drained as much as possible to remove mother liquor and then washed with small amounts of cold alcohol. The solid product is immediately placed in a desiccator and dried over sulfuric acid for about 20 hours.
Therapeutic Function	Antibacterial (leprostatic)

Aldesulfone Sodium Preparation Products And Raw materials

Raw materials

Login