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| | Sulopenem Basic information |
| Product Name: | Sulopenem | | Synonyms: | (S)-3-[[(5R)-2-Carboxy-6β-[(R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]tetrahydrothiophene 1-oxide;CP-65207-S;CP-70429;Sulopenem;(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-, (5R,6S)-;Sulopenem USP/EP/BP;(5R,6S)-6-((R)-1-hydroxyethyl)-3-(((1R)-1-oxidotetrahydrothiophen-3-yl)thio)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid | | CAS: | 120788-07-0 | | MF: | C12H15NO5S3 | | MW: | 349.45 | | EINECS: | 604-604-1 | | Product Categories: | API | | Mol File: | 120788-07-0.mol |  |
| | Sulopenem Chemical Properties |
| Boiling point | 693.1±55.0 °C(Predicted) | | density | 1.74±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 3.88±0.40(Predicted) |
| | Sulopenem Usage And Synthesis |
| Description | Sulopenem is a parenteral penem that demonstrates high activity against Gram-positive, Gram-negative, and anaerobic bacteria. Since it is stable in relation to renal dehydropeptidase I, it does not require concomitant administration of an inhibitor of this enzyme. | | Uses | Antibacterial. | | Uses | Sulopenem is a β-Lactamase inhibitor which is used in treatment of microbial infections. It is an important reagent for many drugs synthesized against bacterial infections. | | Mechanism of action | Sulopenem is one of the penems and, as such, interacts with penicillin-binding proteins (PBPs). From in vitro studies, sulopenem has shown a high affinity for PBP1a, 1b, 2, and 3 in E. coli. | | Pharmacokinetics | When 1 g of CP-65,207 [containing 46.3% of S-isomer (sulopenem)
and 53.7% of R-isomer] was administered by 10-minute intravenous
infusions, the peak concentration of sulopenem in serum was 36.0 mg/
ml, its half-life was 52.8 minutes, and the area under the serum
concentration-versus-time curve (AUC) from 0 to 8 hours was
21.0 mg/ml per hour. |
| | Sulopenem Preparation Products And Raw materials |
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