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Vildagliptin Chloroacetyl Nitrile (R)-Isomer

Vildagliptin Chloroacetyl Nitrile (R)-Isomer Basic information
Product Name:Vildagliptin Chloroacetyl Nitrile (R)-Isomer
Synonyms:2-Pyrrolidinecarbonitrile, 1-(chloroacetyl)-, (2R)- (9CI);(2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile;(R)-1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile;Vildagliptin Impurity 7;Vildagliptin Impurity 15/Vildagliptin Chloroacetyl Nitrile (R)-Isomer/(1S)-2-(2-chloroacetyl)cyclopentane-1-carbonitrile;2-Pyrrolidinecarbonitrile, 1-(2-chloroacetyl)-, (2R)-;(2R)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile;Vildagliptin impurities14
CAS:565452-98-4
MF:C7H9ClN2O
MW:172.61
EINECS:
Product Categories:ACETYLHALIDE;Heterocycles, Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:565452-98-4.mol
Vildagliptin Chloroacetyl Nitrile (R)-Isomer Structure
Vildagliptin Chloroacetyl Nitrile (R)-Isomer Chemical Properties
Melting point 64-67°C
Boiling point 363.1±37.0 °C(Predicted)
density 1.27±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka-4.65±0.40(Predicted)
form Solid
color White to Pale Yellow
Safety Information
MSDS Information
Vildagliptin Chloroacetyl Nitrile (R)-Isomer Usage And Synthesis
Uses(2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile, can be used in the synthesis of 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine, and Vildagliptin (C363780), which are potent, selective, and orally bioavailable dipeptidyl peptidase IV Inhibitor with Antihyperglycemic properties, that might be used for the treatment of type 2 diabetes.
Vildagliptin Chloroacetyl Nitrile (R)-Isomer Preparation Products And Raw materials
2-Pyrrolidinecarbonitrile,1-acetyl-,(2S)-(9CI) Vildagliptin Impurity 25 Vildagliptin Impurity 6 Vildagliptin IMpurity 2 (Mixture of DiastereoMers) (R)-1-(2-chloroacetyl)pyrrolidine-2-carboxaMide N-acetic acid-1-aMino-3-adaMantanol Vildagliptin Impurity 19 1,3,5,7-tetrahydroxyadamantane L-Proline, 4-chloro-, trans- 2-Pyrrolidinecarboxamide,1-(hydroxyacetyl)-,(S)-(9CI) Vildagliptin Carboxylic Acid Vildagliptin iMpurity A-F cis-cyclo(Pro-Pro) methyl D-prolinate D-Prolinamide CHLOROAC-PRO-OH pyrrolidine-2-carbonitrile 2,2,2-trifluoroacetate methyl L-prolinate
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