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| | CIS-ENTACAPONE Basic information |
| Product Name: | CIS-ENTACAPONE | | Synonyms: | (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide;(Z)-Entacapone;CIS-ENTACAPONE;Entacapone impurity A -I;(Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide;Entacapone Impurity 17(Entacapone EP Impurity A);Entacapone Related Compound A (25 mg) ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide);Entacapone EP IMpurity A | | CAS: | 145195-63-7 | | MF: | C14H15N3O5 | | MW: | 305.29 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 145195-63-7.mol |  |
| | CIS-ENTACAPONE Chemical Properties |
| Melting point | 142-144°C | | Boiling point | 526.6±50.0 °C(Predicted) | | density | 1.392±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere | | solubility | Dichloromethane (Slightly), Methanol (Slightly) | | pka | 5.15±0.50(Predicted) | | form | neat | | color | Yellow to Orange |
| | CIS-ENTACAPONE Usage And Synthesis |
| Description | cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone . It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure. | | Chemical Properties | Orange Solid | | Uses | cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian. | | Definition | ChEBI: 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a hydroxycinnamic acid. |
| | CIS-ENTACAPONE Preparation Products And Raw materials |
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