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Ufiprazole

Ufiprazole Basic information
Synthesis
Product Name:Ufiprazole
Synonyms:5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL THIO-1H-BENZIMIDAZOLE;5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYLMERCAPTOBENZIMIDAZOLE;5-METHOXY-2-[[(3,5-DIMETHYL-4-METHOXY PYRIDINYL)-METHYL]THIO]-1H-BENZIMIDAZOLE;2-[(4-METHOXYETHOXY-3,5-DIMETHYL-2-PYRIDINYL)-METHYLTHIO]-5-METHOXYBENZIMIDAZOLE;2-{[(3,5-dimethyl-4-methoxy-2-pyridinyl)-methyl]-thio}-5-methoxy-1h-benzimidazole;OMEPRAZOLE SULPHIDE;H 168/22;ufiprazole
CAS:73590-85-9
MF:C17H19N3O2S
MW:329.42
EINECS:615-997-3
Product Categories:zjh;Inhibitors;(intermediate of lamivudine);Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Various Metabolites and Impurities;73590-85-9
Mol File:73590-85-9.mol
Ufiprazole Structure
Ufiprazole Chemical Properties
Melting point 122.0 to 126.0 °C
Boiling point 539.7±60.0 °C(Predicted)
density 1.28±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka9.81±0.10(Predicted)
color White to Off-White
λmax307nm(MeOH)(lit.)
InChIInChI=1S/C17H19N3O2S/c1-10-8-18-15(11(2)16(10)22-4)9-23-17-19-13-6-5-12(21-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChIKeyXURCIPRUUASYLR-UHFFFAOYSA-N
SMILESC1(SCC2=NC=C(C)C(OC)=C2C)NC2=CC(OC)=CC=C2N=1
CAS DataBase Reference73590-85-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
HS Code 29339900
MSDS Information
Ufiprazole Usage And Synthesis
SynthesisUfiprazole can be synthesized by the condensation reaction of 2-mercapto-5-methoxybenzimidazole and 2-chloromethyl-4-methoxy-3,5-lutidine.
DescriptionOmeprazole sulfide is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazole . As a degradation product, it is reported to be a direct-acting inhibitor of cytochrome P450 2C19 in pooled human liver microsomes (IC50 = 9.7 μM).
UsesOmeprazole Sulfide (Esomeprazol EP Impurity C(Omeprazole EP Impurity C)) is a metabolite of Omeprazole.
DefinitionChEBI: Omeprazole sulfide is a member of benzimidazoles.
Biological ActivityUfiprazole (Omeprazole sulfide) is an intermediate in the production of gastric proton pump inhibitors omeprazole and esomeprazole.
Ufiprazole Preparation Products And Raw materials
Raw materials2-MERCAPTO-5-METHOXYBENZIMIDAZOLE
Preparation ProductsOMEPRAZOLE-->Esomeprazole magnesium-->Omeprazole
5-METHOXY-2-[((4-METHOXY-3,5-DIMETHYL-1-OXIDO-2-PYRIDINYL)METHYL)SULFINYL]-BENZIMIDAZOLE 2-[(5-CARBOXY-4-METHOXY-3-METHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE Omeprazole OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Omeprazole sodium OMEPRAZOLE IMP. C (EP): 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]SULPHANYL]-1H-BENZIMIDAZOLE (UFIPRAZOLE) 2[(4-METHOXY-5-HYDROXYMETHYL-3-METHYLPYRID-2-YL)-METHYLTHIO]-5-METHOXYBENZIMIDAZOLE Cytosine 5-HYDROXY OMEPRAZOLE 2[(4-METHOXY-5-METHOXYCARBONYL-3-METHYLPYRID-2-YL)-METHYLTHIO]-5-METHOXYBENZIMIDAZOLE Ufiprazole Esomeprazole 1-CHLOROMETHYL-5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-PYRIDIN-2-YLMETHANESULFINYL)-1H-BENZOIMIDAZOLE Esomeprazole potassium Esomeprazole sodium OMEPRAZOLE-D3 (BENZIMIDAZOLE-4,6,7-D3) 2-[(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)-METHYLTHIO]-5-BENZOYLOXYBENZIMIDAZOLE Esomeprazole magnesium trihydrate
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