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| | 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Basic information |
| Product Name: | 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide | | Synonyms: | 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide;ML251;2-(3,4-Dichlorophenyl)-N-(4-(N-(isoxazol-3-yl)sulfamoyl)phenyl)acetamide;cruzi,inhibit,brucei,MRC-5,Inhibitor,nanomolar,Parasite,ML-251,ML 251,ML251 | | CAS: | 1486482-16-9 | | MF: | C17H13Cl2N3O4S | | MW: | 426.27382 | | EINECS: | | | Product Categories: | | | Mol File: | 1486482-16-9.mol | ![2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Structure](CAS/20180601/GIF/1486482-16-9.gif) |
| | 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (586.48 mM; Need ultrasonic) |
| | 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Usage And Synthesis |
| Biological Activity | ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].
ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1]. | | References | [1]. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17. |
| | 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide Preparation Products And Raw materials |
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