ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline

1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline

1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline Basic information
Product Name:1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline
Synonyms:1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline;(2S)-1-[(2S)-3-Bromo-2-methylpropanoyl]pyrrolidine-2-carboxylic acid;Captopril impurity B;(S)-1-((S)-3-bromo-2-methylpropanoyl)pyrrolidine-2-carboxylic acid;Captopril Impurity 2(Captopril EP Impurity B);1-(3-bromo-2S-methylpropionyl)-pyrrolidine-2S-carboxylic acid;L-Proline, 1-(3-bromo-2-methyl-1-oxopropyl)-, (S)-;captopril-ep-imp-B
CAS:80629-35-2
MF:C9H14BrNO3
MW:264.12
EINECS:
Product Categories:Inhibitors, Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:80629-35-2.mol
1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline Structure
1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline Chemical Properties
Melting point 110-114℃
Boiling point 425.1±40.0 °C(Predicted)
density 1.555±0.06 g/cm3(Predicted)
pka3.52±0.20(Predicted)
form neat
Safety Information
MSDS Information
1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline Usage And Synthesis
Uses1-[(2S)-3-Bromo-2-methyl-1-oxopropyl]-L-proline is an intermediate in the synthetic preparation of Captopril (C175750), a orally active angiotensin-converting enzyme (ACE) inhibitor.
1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline Preparation Products And Raw materials
Raw materialsPropanoyl chloride, 3-bromo-2-methyl--->L-Proline
Bromisoval Captopril 1-[(2R)-2-Methyl-3-mercaptopropionyl]proline 3-MERCAPTOISOBUTYRIC ACID 2-bromo-4-methylpropiophenone 2-Bromo-2-methylpropane CAPTOPRIL DISULFIDE (2S)-1-[2-Methylpropanoyl]-pyrrolidine-2-carboxylic Acid
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