2-(Hydroxymethyl)pyridine

2-(Hydroxymethyl)pyridine Basic information

Product Name:	2-(Hydroxymethyl)pyridine
Synonyms:	2-Pyridine methanol(2-hydromethyl pyridine);2-HYDROXYMETHYLPYRIDINE(PYRIDINE-2-CARBINOL);2-Pyridinemethanol,ω-Hydroxy-2-picoline, 2-(Hydroxymethyl)pyridine, 2-Pyridyl carbinol;2-(Hydroxymethyl)pyr;2-HYDROXYMETHYL PYRIDINE PYRIDIN-2-YL-METHANOL;PYRIDINE-2-METHANOL (2-PYRIDYLCARBINOL);2-Pyridine Methanol 99%;ω-Hydroxy-2-picoline, 2-(Hydroxymethyl)pyridine, 2-Pyridyl carbinol
CAS:	586-98-1
MF:	C6H7NO
MW:	109.13
EINECS:	209-592-7
Product Categories:	Building Blocks;C6;Pyridine;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines;bc0001
Mol File:	586-98-1.mol

2-(Hydroxymethyl)pyridine Chemical Properties

Melting point	5 °C
Boiling point	112-113 °C/16 mmHg (lit.)
density	1.131 g/mL at 25 °C (lit.)
vapor pressure	3.47Pa at 25℃
refractive index	n20/D 1.543(lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	miscible
form	Liquid
pka	13.48±0.10(Predicted)
color	Clear colorless to yellow or brown
Specific Gravity	1.131
PH	6-8 (100g/l, H2O, 20℃)
Odor	pyridine odor
Water Solubility	miscible
Sensitive	Hygroscopic
BRN	107849
InChIKey	SHNUBALDGXWUJI-UHFFFAOYSA-N
LogP	0.11
CAS DataBase Reference	586-98-1(CAS DataBase Reference)
NIST Chemistry Reference	Piconol(586-98-1)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-22
Safety Statements	26-36-37/39
WGK Germany	3
RTECS	UT4689000
F	3-8
Hazard Note	Irritant/Keep Cold/Hygroscopic
HazardClass	IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code	29333999

MSDS Information

2-(Hydroxymethyl)pyridine Usage And Synthesis

Chemical Properties	CLEAR COLORLESS TO YELLOW OR BROWN LIQUID
Uses	decongestant
Uses	A pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells.
Uses	2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity.
Preparation	The preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids.
Definition	ChEBI: 2-Pyridinylmethanol is a member of pyridines.

2-(Hydroxymethyl)pyridine Preparation Products And Raw materials

Raw materials	Methanol-->4-Pyridylcarbinol-->2-Cyanopyridine
Preparation Products	2-Chloro-5-hydroxymethylpyridine-->2-(2-Pyridyl)benzoxazole-->Methyl picolinate-->Ethyl picolinate-->2-(Bromomethyl)pyridine-->1-PYRIDIN-2-YLMETHYL-PIPERAZINE-->2,2'-DIPICOLYLAMINE-->2-(2-PYRIDYL)BENZIMIDAZOLE

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