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| | SENEGENIN Basic information |
| Product Name: | SENEGENIN | | Synonyms: | SENEGENIN;SENEGIN;13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid;28-dioicacid,12-(chloromethyl)-2-beta,3-beta-dihydroxy-27-noro-13-ene-2;27-Norolean-13-ene-23,28-dioicacid, 12-(chloromethyl)-2,3-dihydroxy-, (2β,3β,4α,12α)-;Tenuigenin;12α-(Chloromethyl)-2β,3β-dihydroxy-27-nor-5α-olean-13-ene-23,28-dioic acid;12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid | | CAS: | 2469-34-3 | | MF: | C30H45ClO6 | | MW: | 537.13 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 2469-34-3.mol |  |
| | SENEGENIN Chemical Properties |
| Melting point | 290-292℃ | | alpha | D +19° (c = 0.70 in ethanol) | | Boiling point | 674.1±55.0 °C(Predicted) | | density | 1.28 | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | pka | 4.27±0.70(Predicted) | | form | powder | | color | white to beige |
| WGK Germany | 3 | | RTECS | RC8815000 | | Toxicity | LD50 intraperitoneal in mouse: 3mg/kg |
| | SENEGENIN Usage And Synthesis |
| Description | Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia. | | Uses | Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease. | | Definition | ChEBI: Senegenin is a 12alpha-hydroxy steroid. |
| | SENEGENIN Preparation Products And Raw materials |
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