ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide

(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide

(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide Basic information
Product Name:(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide
Synonyms:(S)-N-1-azabicyclo[2.2.0]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide;(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide;(S)-N-(Quinuclidin-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxaMide;N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxaMide;N-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl] 5,6,7,8-tetrahydronaphthalene-1-carboxamide;Palonosetron Impurity 3;Palonosetron Intermediate;Palonosetron Impurity 20
CAS:135729-78-1
MF:C18H24N2O
MW:284.4
EINECS:
Product Categories:Intermediate of palonosetron hcl
Mol File:135729-78-1.mol
(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide Structure
(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide Chemical Properties
Melting point 157-159oC
Boiling point 439.2±45.0 °C(Predicted)
density 1.17
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka14.75±0.20(Predicted)
color White
Safety Information
MSDS Information
(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide Usage And Synthesis
Uses(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide is an impurity in the synthesis of Palonosetron HCl (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide Preparation Products And Raw materials
Raw materials5,6,7,8-TETRAHYDRO-NAPHTHALENE-1-CARBONYL CHLORIDE-->5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid-->(S)-quinuclidin-3-aMine-->Oxalyl chloride
Preparation ProductsPalonosetron
1H-Benz[de]isoquinolin-1-one,2,4,5,6-tetrahydro-2-[(3S)-1-oxido-1-azabicyclo[2.2.2]oct-3-yl]- PLSQ-001 TM4-QJ 5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid N,N-Diethyl-5,6,7,8-tetrahydronaphthalene-1-carboxamide (1S)-N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-1,2,3,4-tetrahydro-1-naphthalenecarboxaMide-d1 (3S)-AMinoquinuclidine-D1 Dihydrochloride Palonosetron Impurity 7 2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinoline 2H-Naphtho[1,8-bc]furan-2-one, 6,7,8,8a-tetrahydro- Palonosetron Impurity 8 Palonosetron Impurity 6 HCl Palonosetron Hydrochloride Formamide,Deionized 2-(S)-1-AZA-BICYCLO[2.2.2]OCT-3-YL-3-HYDROXY-2,3,3A,4,5,6-HEXAHYDRO-BENZO[DE]ISOQUINOLIN-1-ONE (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide (S)-2-(1-AZA-BICYCLO[2.2.2]OCT-3-YL)-2,4,5,6-TETRAHYDRO-BENZO[DE]ISOQUINOLIN-1-ONE 5,6,7,8-TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID (1-AZA-BICYCLO[2.2.2]OCT-3-YL)-AMIDE (S)-(S)-2-(1-AZA-BICYCLO[2.2.2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-BENZO[DE]ISOQUINOLIN-1-ONE
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