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Ophthazin

Ophthazin Basic information
Product Name:Ophthazin
Synonyms:LABOTEST-BB LT00439820;DIHYDRALAZINE;Ophthazin;1,4-dihydrazinonaphthalazine;1,4-dihydrazino-phthalazin;1,4-dihydrazinophthalazine;2,3-dihydro-1,4-phthalazinedionedihydrazone;4-phthalazinedione,2,3-dihydro-dihydrazone
CAS:484-23-1
MF:C8H10N6
MW:190.21
EINECS:207-605-0
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:484-23-1.mol
Ophthazin Structure
Ophthazin Chemical Properties
Melting point 180°C (rough estimate)
Boiling point 315.71°C (rough estimate)
density 1.3243 (rough estimate)
refractive index 1.8100 (estimate)
pka3?+-.0.20(Predicted)
color Orange crystals from H2O
Safety Information
HS Code 2933998090
ToxicityLD50 i.p. in rats: 1084 mmol/kg (Steiner)
MSDS Information
Ophthazin Usage And Synthesis
OriginatorNepresol,Novartis
UsesOphthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.
DefinitionChEBI: Dihydralazine is a member of phthalazines.
Manufacturing Process115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.
Therapeutic FunctionAntihypertensive
Safety ProfilePoison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.
Ophthazin Preparation Products And Raw materials
Raw materialsHydrazine hydrate-->Phthalonitrile
Sofalcone Losartan potassium HEXABROMOBENZENE Nifedipine Bismuth subcarbonate ZINC TELLURIDE Minoxidil Magnesium trisilicate guanethidine Ophthazin Hydralazine Dihydralazine sulphate Phthalhydrazide Hydrochlorothiazide Phthalazine Pyridazine
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