ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE

2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE

2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE Basic information
Product Name:2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
Synonyms:2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE;5-(Trifluoromethyl)-2-(chloromethyl)-1,3,4-oxadiazole;1,3,4-Oxadiazole, 2-(chlo...;1,3,4-Oxadiazole, 2-(chloroMethyl)-5-(trifluoroMethyl)-;2-Chloromethyl-5-trifluoromethyl trifluoromethyl -[1,3,4]oxadiazole;Sitagliptin Impurity 65;2-(Chloromethyl)-5-(trifluromethyl)-1,3,4-oxadiazole
CAS:723286-98-4
MF:C4H2ClF3N2O
MW:186.52
EINECS:
Product Categories:Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Compounds
Mol File:723286-98-4.mol
2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE Structure
2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE Chemical Properties
Boiling point 55-60 °C(Press: 10 Torr)
density 1.555±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Soluble), Methanol (Sparingly)
pka-8.11±0.44(Predicted)
form Oil
color Pale Yellow to Yellow
CAS DataBase Reference723286-98-4
Safety Information
HS Code 2929900090
MSDS Information
2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE Usage And Synthesis
Chemical PropertiesYellow Liquid
UsesSitagliptin intermediate. An anti-hypertensive agent for the treatment of diabetes and hypertension.
2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE Preparation Products And Raw materials
Raw materials1-(Chloroacetyl)-2-(trifluoroacetyl)hydrazine-->TRIFLUOROACETIC ACID HYDRAZIDE-->Chloroacetyl chloride-->Trifluoroacetic anhydride
Sitagliptin Impurity 77 Sitagliptin Impurity 46 Sitagliptin Impurity 28 2-Pentafluorophenyl-malonic acid diethyl ester 2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE (S)-Sitagliptin Phosphate Sitagliptin DeaMino IMpurity 1 Sitagliptin Defuoro IMpurity 5 Sitagliptin Impurity 14 (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione Sitagliptin Impurity 12 2,6,9,13-Tetraazatetradecanedioic acid, 5,10-dioxo-3,12-bis[(2,4,5-trifluorophenyl)methyl]-, 1,14-bis(1,1-dimethylethyl) ester, (3R,12R)- 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- (R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate hydrochloride 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
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