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ZOPICLONE N-OXIDE

ZOPICLONE N-OXIDE Basic information
Product Name:ZOPICLONE N-OXIDE
Synonyms: RP 2975;1-Piperazine-carboxylic Acid 4-Methyl-4-oxide 6-(5-Chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5yl Ester;Zopiclone N-Oxide (Mixture of diastereomers);RP 29753;Zopiclone N-Oxide (Eszopiclone Impurity A) (Mixture of Diastereomers);Zopiclone N-Oxide (Eszopiclone Impurity A) ;ZOPICLONE N-OXIDE;4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester 4-oxide
CAS:43200-96-0
MF:C17H17ClN6O4
MW:404.81
EINECS:641-896-9
Product Categories:Isotopically Labeled Pharmaceutical Reference Standard;Heterocycles;Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:43200-96-0.mol
ZOPICLONE N-OXIDE Structure
ZOPICLONE N-OXIDE Chemical Properties
Melting point >140°C (dec.)
Fp 9℃
storage temp. 2-8°C
solubility Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form neat
pka4.92±0.20(Predicted)
color White to Light Brown
Safety Information
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25
Safety Statements 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol
WGK Germany 1
HS Code 2933790002
MSDS Information
ZOPICLONE N-OXIDE Usage And Synthesis
Chemical PropertiesOff-White to Pale Beige Solid
UsesA metabolite of Zopiclone
UsesEszopiclone impurity A.
General DescriptionZopiclone N-oxide is a primary, active metabolite of zopiclone in urine as well as a major pharmaceutical impurity of zopiclone known as eszopiclone impurity A. The parent drug, zopiclone, is a non-benzodiazepine hypnotic sold under the trade names Imovane?and ZImovane?and is used in the treatment of insomnia.
ZOPICLONE N-OXIDE Preparation Products And Raw materials
RP 48497 (Eszopiclone Impurity C) Zopiclone Impurity 10 Zopiclone Impurity 18 Zopiclone Impurity 3 N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide ZOPICLONE OXIDE Eszopiclone N-Oxide Levetiracetam impurity 1 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one Zopiclone iMpurity (5-(Chloropyridine-2-yl-carbaMoyl)pyrazine) 6-(5-Chloro-2-pyridyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione Zopiclone iMpurity A N-Boc-N-desmethyl Zopiclone ZOPICLONE N-OXIDE N-DESMETHYL ZOPICLONE Trimethylamine N-oxide Piperazine D8 N-METHYLPIPERAZINE-3,3,5,5-D4
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