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| | Hydroxysafflor yellow A Basic information |
| Product Name: | Hydroxysafflor yellow A | | Synonyms: | SAFFLOMIN A;Hydroxysafflor yellow A;2,5-Cyclohexadien-1-one, 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-((2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl)-;Hydroxysafflor yellow A,SaffloMin A,HSYA;Hydroxysafflor yellow A,Safflomin A;Hydroxysafflor yellow;Safflomin A, 98%, from Carthamus tinctorius L.;HSYA | | CAS: | 78281-02-4 | | MF: | C27H32O16 | | MW: | 612.54 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 78281-02-4.mol |  |
| | Hydroxysafflor yellow A Chemical Properties |
| Melting point | 184-186 °C | | Boiling point | 1015.8±65.0 °C(Predicted) | | density | 1.851±0.06 g/cm3(Predicted) | | solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; PBS (pH 7.2): 1 mg/ml | | pka | 4.50±1.00(Predicted) | | form | powder | | color | Yellow-orange | | LogP | 1.688 (est) |
| Safety Statements | 24/25 | | HS Code | 29389090 |
| | Hydroxysafflor yellow A Usage And Synthesis |
| Definition | ChEBI: Hydroxysafflor yellow A is a C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius). It has a role as an anti-inflammatory agent, an antioxidant, a platelet aggregation inhibitor, an antineoplastic agent, a radical scavenger, an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor, a neuroprotective agent and a plant metabolite. It is a C-glycosyl compound, a member of phenols, an enone and an enol. | | Biological Activity | Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities. It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 μM. | | in vivo | Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats. It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral is chemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg. |
| | Hydroxysafflor yellow A Preparation Products And Raw materials |
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