4-Fluorophenol

4-Fluorophenol Basic information

Product Name:	4-Fluorophenol
Synonyms:	p-Fluorphenol;Phenol, p-fluoro-;4-FLUOROPHENOL;AKOS BBS-00004253;P-FLUOROPHENOL;Fluorophenoloffwhiteflakes;p-Fluorophenol,99%;Phenol, 4-fluoro-
CAS:	371-41-5
MF:	C6H5FO
MW:	112.1
EINECS:	206-736-0
Product Categories:	alcohol\| alkyl Fluorine;organofluorine compounds;Aryl Fluorinated Building Blocks;Building Blocks;C6;Pyridines;Fluoro-Aromatics;C6 to C8;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Oxygen Compounds;Liquid Crystal intermediates;Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Building Blocks for Liquid Crystals;Functional Materials;Phenols (Building Blocks for Liquid Crystals);Pharmaceutical Intermediate;Organic Building Blocks;Oxygen Compounds;Phenols;371-41-5
Mol File:	371-41-5.mol

4-Fluorophenol Chemical Properties

Melting point	43-46 °C (lit.)
Boiling point	185 °C (lit.)
density	1.22
Fp	155 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	80g/l
form	Crystalline Solid
pka	9.89(at 25℃)
color	Yellow-beige to pink
PH	5.4 (H2O, 20℃)(saturated aqueous solution)
Water Solubility	50 g/L
BRN	1362752
Stability:	Stable. Flammable. Incompatible with strong oxidizing agents.
Dissociation constant	0 at 27℃
CAS DataBase Reference	371-41-5(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 4-fluoro-(371-41-5)
EPA Substance Registry System	Phenol, 4-fluoro- (371-41-5)

Safety Information

Hazard Codes	Xn,C,T,F+
Risk Statements	20/21/22-36/37/38-52/53
Safety Statements	26-37/39-61-36
RIDADR	UN 2928 6.1/PG 2
WGK Germany	1
RTECS	SL4550000
F	10-23
Hazard Note	Corrosive/Harmful
TSCA	T
HazardClass	6.1
PackingGroup	III
HS Code	29081000

MSDS Information

Provider	Language
4-Fluorophenol	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Fluorophenol Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	4-Fluorophenol is a fluorinated phenolic compound with various applications as a starting reagent for synthesizing pharmaceuticals. It is a widely used intermediate in the industrial production of several drugs, including cisapride and Sabeluzole by Janssen, Sorbinil by Pfizer, and Progabide by Synthelabo.
Definition	ChEBI: 4-fluorophenol is a fluorophenol that is phenol in which the hydrogen para- to the hydroxy group has been replaced by a fluorine. It is a fluorophenol and a member of monofluorobenzenes. It is used as an intermediate in the production of liquid crystals.
Preparation	Acetyl hypofluorite also will fluoro-demetallate benzene derivatives, for example mercury derivatives of phenol gave 4-fluorophenol.
Synthesis Reference(s)	Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Hazard	Irritant.

4-Fluorophenol Preparation Products And Raw materials

Raw materials	Hydrogen-->4-Chloronitrobenzene-->2,5-Cyclohexadien-1-one, 4,4-difluoro--->1-fluoro-4-(prop-2-en-1-yloxy)benzene-->2-(4-FLUOROPHENYL)-5,5-DIMETHYL-1,3,2-DIOXABORINANE-->5-FLUORO-2-METHOXYBENZOIC ACID-->4-tert-Butylphenol-->Phenol-->4-Fluorobenzeneboronic acid-->4-Fluorostyrene-->4-Fluoroanisole-->1-Fluoro-4-iodobenzene-->Hydrogen peroxide-->4-Bromofluorobenzene-->2,5-Difluorophenol
Preparation Products	Fluoxetine-->FLUMICLORAC-PENTYL-->(4-FLUOROPHENOXY)ACETYL CHLORIDE-->3-(4-Fluorophenoxy)propionic acid-->4-Hydroxyphenylboronic acid pinacol ester-->2-Chloro-4-fluorophenol

Pentafluorophenol 2-Phenylphenol SODIUM PHENOLATE TRIHYDRATE Acetaminophen 4-tert-Butylphenol 2,4-Difluorophenol 2,6-Difluorophenol 2-Bromo-4-fluoroanisole 4-Fluorophenoxyacetic acid 4-Fluorobenzonitrile 2,4-DIFLUORO-1-METHOXYBENZENE p-Cresol 4-Aminophenol 2-Chloro-4-fluorophenol 99% 4-Nitrophenol 2-Bromo-4-fluorophenol 97%,2-Bromo-4-fluorophenol,98+% 3,4,5-Trifluorophenol 4-Fluorophenol

Email:[email protected] [email protected]

Copyright © 2024 Mywellwork.com All rights reserved.