2,4-Dinitrofluorobenzene

2,4-Dinitrofluorobenzene Basic information
Product Name:2,4-Dinitrofluorobenzene
Synonyms:2,4-Dinitrofluorobenzene,98%;2,4-Dinitrofluoroben;4-Dinitrofluorobenzene;4-Fluoro-1,3-dinitrobenzene;NSC 33519;(T)2,4-DINITRO-1-FLUOROBENZENE;1,1′-Bis(1-dinaphthylphosphino)ferrocene;1-Fluoro-2,4-dinitrobenzene 〔2,4-Dinitrofluorobenzene〕
CAS:70-34-8
MF:C6H3FN2O4
MW:186.1
EINECS:200-734-3
Product Categories:Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Organics;Amino Group Labeling Reagents for HPLC;Analytical Chemistry;HPLC Labeling Reagents;UV Detection (HPLC Labeling Reagents);Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry;Fluorobenzene
Mol File:70-34-8.mol
2,4-Dinitrofluorobenzene Structure
2,4-Dinitrofluorobenzene Chemical Properties
Melting point 25-27 °C (lit.)
Boiling point 178 °C/25 mmHg (lit.)
density 1.482 g/mL at 25 °C (lit.)
refractive index n20/D 1.569(lit.)
Fp >230 °F
storage temp. 2-8°C
solubility chloroform: 0.1 g/mL, clear
form Liquid or Low Melting Crystals
color Yellow to brownish
Specific Gravity1.482
Water Solubility 400 mg/L (25 ºC)
Merck 14,4172
BRN 398632
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference70-34-8(CAS DataBase Reference)
NIST Chemistry ReferenceBenzene, 1-fluoro-2,4-dinitro-(70-34-8)
EPA Substance Registry System2,4-Dinitrofluorobenzene (70-34-8)
Safety Information
Hazard Codes C,T,Xn
Risk Statements 22-33-34-42/43-40-23/24/25-43-36/38-36/37/38
Safety Statements 22-26-36/37/39-45-28A-23-7/9-36/37
RIDADR UN 3261 8/PG 2
WGK Germany 3
RTECS CZ7800000
Hazard Note Toxic
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29049085
Hazardous Substances Data70-34-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
DNFB English
SigmaAldrich English
ALFA English
2,4-Dinitrofluorobenzene Usage And Synthesis
Chemical PropertiesYellow solid
Uses1-Fluoro-2,4-dinitrobenzene is used to identify the amino acid sequence. It reacts with amino group of amino acids to yield dinitrophenyl-amino acids. It is also used in chromatographic methods. Further, it acts as an alkylating agent used in elucidating amino acid sequence in proteins.
UsesA substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.
DefinitionChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.
General DescriptionClear yellow crystals or yellow crystalline solid.
Air & Water ReactionsSlightly soluble in water.
Reactivity ProfileReacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.
Fire Hazard2,4-Dinitrofluorobenzene is probably combustible.
Biochem/physiol Actions1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity, inducing itch model, and atopic dermatitis. Mast cell activation is a key step in the DNFB induced sensitivity. DNFB covalently binds to the N-terminal amino acid of the protein and aids in Sanger sequencing.
Contact allergensDNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata
Safety ProfilePoison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data reported. Solutions in ether may explode when evaporated* When heated to decomposition it emits highly toxic fumes of NOx and F-. See also NITRO E COMPOUNDS of AROMATIC HYDROCARBONS and FLUORIDES.
Purification MethodsCrystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.]
AURORA KA-7916 FDNP-VAL-NH2 2,4-DINITRO-5-FLUOROANILINE FDNP-D-ALA-NH2 N(ALPHA)-(2 4-DINITRO-5-FLUOROPHENYL)- 2,4-DINITRO-5-FLUOROBENZOIC ACID 1,3-Difluoro-2,4-dinitrobenzene, 98% 1-CHLORO-5-FLUORO-2,4-DINITROBENZENE ACRYLONITRILE SOLUTION 1000UG/ML IN METHANOL 1ML DIELDRIN SOLUTION 100UG/ML IN METHANOL 5ML NALPHA-(5-FLUORO-2,4-DINITROPHENYL)-L-LEUCINAMIDE 2,4-DINITRO-5-FLUOROACETANILIDE 2,4-DINITRO-5-FLUOROTOLUENE BENDIOCARB SOLUTION 1000UG/ML IN ACETONITRILE 5X1ML DICROTOPHOS SOLUTION 100UG/ML IN TOLUENE 5X1ML NALPHA-(5-FLUORO-2,4-DINITROPHENYL)-D-LEUCINAMIDE fluoro jade 3-BROMO-4,6-DINITROFLUOROBENZENE

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.