|
| | Cilazapril Basic information |
| Product Name: | Cilazapril | | Synonyms: | 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-;6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-;Ro 31-2848;Yipingshu;CILASTATIN NA;CILASTATIN SODIUM SALT;sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate;(1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid | | CAS: | 88768-40-5 | | MF: | C22H31N3O5 | | MW: | 417.5 | | EINECS: | 641-006-9 | | Product Categories: | Chiral Reagents;API;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 88768-40-5.mol |  |
| | Cilazapril Chemical Properties |
| Melting point | 95-97°C | | Boiling point | 598.1±60.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly) | | form | powder | | pka | 2.28±0.20(Predicted) | | color | White to Off-White | | CAS DataBase Reference | 88768-40-5(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | MJ9650200 |
| | Cilazapril Usage And Synthesis |
| Description | Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension. | | Chemical Properties | Off-White Solid | | Uses | An ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive. | | Definition | ChEBI: Cilazapril is a pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is an ethyl ester, a pyridazinodiazepine and a dicarboxylic acid monoester. It is functionally related to a Cilazaprilat. | | Brand name | Inhibace (Hoffmann-LaRoche). |
| | Cilazapril Preparation Products And Raw materials |
|
