(2-BROMO-2-ETHYLBUTYRYL)UREA

(2-BROMO-2-ETHYLBUTYRYL)UREA Basic information
Product Name:(2-BROMO-2-ETHYLBUTYRYL)UREA
Synonyms:(2-bromo-2-ethylbutyryl)-ure;(2-bromo-ethylbutyryl)-ure;(alpha-Bromo-alpha-ethylbutyryl)carbamide;(alpha-Bromo-alpha-ethylbutyryl)urea;(alpha-Ethyl-alpha-bromobutyryl)urea;BROMODIETHYLACETYLUREA;BROMADAL;CARBROMAL
CAS:77-65-6
MF:C7H13BrN2O2
MW:237.09
EINECS:201-046-6
Product Categories:
Mol File:77-65-6.mol
(2-BROMO-2-ETHYLBUTYRYL)UREA Structure
(2-BROMO-2-ETHYLBUTYRYL)UREA Chemical Properties
Melting point 116-119°
density 1.5528 (rough estimate)
refractive index 1.5140 (estimate)
Water Solubility 0.5g/L(20 ºC)
Stability:Stable. Combustible. Incompatible with acids, alkalies, strong oxidizing agents.
EPA Substance Registry SystemCarbromal (77-65-6)
Safety Information
Hazardous Substances Data77-65-6(Hazardous Substances Data)
ToxicityLD50 oral in rat: 316mg/kg
MSDS Information
(2-BROMO-2-ETHYLBUTYRYL)UREA Usage And Synthesis
Chemical Propertieswhite crystalline powder
OriginatorAntineuralgiae,Jelfa
DefinitionChEBI: Carbromal is a N-acylurea.
Manufacturing Process120 parts urea and 258 parts 2-bromo-2-ethylbutyrylbromide was mixed and stood at room temperature for 12 hours; then the mixture was heated about 3 hours on water bath and adjusted to alkaline pH with sodium bicarbonate after cooling. The unreacted products was dissolved in brine, the insoluble part was filtered off. The recrystallization from ethanol gave the title product - (2-bromo-2-ethyl-butyryl)urea as the colorless, odorless crystals. MP 114°- 118°C.
Brand nameAdalin (Sterling Winthrop).
Therapeutic FunctionHypnotic, Sedative
General DescriptionOdorless tasteless white crystalline powder. Saturated solution in water neutral to litmus.
Air & Water ReactionsMay be sensitive to prolonged exposure to air and light. Insoluble in water.
Reactivity ProfileThe neat material may be sensitive to prolonged exposure to air and light. (2-BROMO-2-ETHYLBUTYRYL)UREA is incompatible with acids and alkalis.
Fire HazardFlash point data for (2-BROMO-2-ETHYLBUTYRYL)UREA are not available; however, (2-BROMO-2-ETHYLBUTYRYL)UREA is probably combustible.
Safety ProfilePoison by ingestion, subcutaneous, and possibly other routes. Moderately toxic via intravenous and intraperitoneal routes. Mutation data reported. A sedative, hypnotic, and central Intdious system depressant. When heated to decomposition it emits very toxic fumes of NOx and Br-.
(2-BROMO-2-ETHYLBUTYRYL)UREA Preparation Products And Raw materials
Raw materials2-BROMO-2-ETHYLBUTYRYL BROMIDE-->N-carbamoyl-2-ethylbutyraldehyde-->Butanoic acid, 2-[[(aminocarbonyl)amino]carbonyl]-2-ethyl--->carbamoyl chloride-->Methanol-->cyanic acid
Preparation Productsectylurea
ACETYLUREA 3-BROMOPENTANE 2-BROMOPROPIONAMIDE 2-BROMO-ISONICOTINIC ACID METHYL ESTER 2-BROMOBUTYRAMIDE 2-BROMO-2-METHYLBUTANE 2-BROMO-2-METHYLPROPANAMIDE 3-BROMO-3-METHYLPENTANE 2-BROMO-2-METHYL-PROPIONALDEHYDE acetyl carbromal (2-BROMO-2-ETHYLBUTYRYL)UREA

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