4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE)

4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE) Basic information
Product Name:4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE)
Synonyms:ATENOLOL IMPURITY E;4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE);4,4'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetaMide (Atenolol IMpurity E);Atenolol Impurity 5(Atenolol EP Impurity E);2,2'-[(2-Hydroxypropane-1,3-diyl)bi;Benzeneacetamide, 4,4'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis-;4,4'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide;2-[4-[3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxypropoxy]phenyl]acetamide
CAS:141650-31-9
MF:C19H22N2O5
MW:358.39
EINECS:
Product Categories:Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:141650-31-9.mol
4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE) Structure
4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE) Chemical Properties
Melting point >205°C (dec.)
Boiling point 696.1±55.0 °C(Predicted)
density 1.280±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
pka13.35±0.20(Predicted)
form Solid
color Off-White to Light Brown
Safety Information
MSDS Information
4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE) Usage And Synthesis
Uses4,4''-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker. Atenolol EP Impurity E
Uses4,4'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker.
4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE) Preparation Products And Raw materials
Metoprolol Acid IMp. H (EP): 2-[4-[(2RS)-2-Hydroxy-3-[(1-Methylethyl)aMino]propoxy]phenyl]acetonitrile 2-[4-(2,3-EPOXYPROPOXY)PHENYL]ACETAMIDE 2-[4-(2,3-DIHYDROXYPROPOXY)PHENYL]ACETAMIDE Atenolol 2-[4-(3-CHLORO-2-HYDROXYPROPOXY)PHENYL]ACETAMIDE 4-Hydroxyphenylacetamide 2,2'-(4,4'-(3,3'-(isopropylazanediyl)bis(2-hydroxypropane-3,1-diyl))bis(oxy)bis(4,1-phenylene))diacetaMide 2-Phenylacetamide 4,4'-(2-HYDROXY-1,3-PROPANDIYLDIOXY)BIS(2-PHENYLACETAMIDE) ATENOLOL-D7 C-Desmethyl Atenolol 4-(3-Amino-2-hydroxypropoxy)phenylacetamide 4-Hydroxyphenylacetic acid [[p-(2-methoxyethyl)phenoxy]methyl]oxirane Atenolol EP Impurity G Sodium Salt 2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE

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